von Willbrand factor Thr789Ala gene variant determines the type of myocardial ischemia in Egyptian patients

Objective von Willbrand factor antigen level (vWF: Ag) was shown to contribute to the risk of cardiovascular disease. vWF Thr789Ala single nucleotide polymorphism was thought to affect the factor level and function. This study aimed to investigate the impact of genetic variants at that position on t...

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Published in:The Egyptian journal of haematology : the official journal of the Egyptian Society of Haematology 2018-10, Vol.43 (4), p.206-211
Main Authors: Osman, Nahla, Younes, Marwa, Yaseen, Reehab, Fathy, Amro
Format: Article
Language:English
Subjects:
Angina pectoris
Antigens
Cardiovascular diseases
Coronary heart disease
EDTA
Enzyme-linked immunosorbent assay
Enzymes
Genetic aspects
Genetic polymorphisms
Genetic research
Genetic variation
Heart attack
Ischemia
Medical research
Myocardial ischemia
Risk factors
Single nucleotide polymorphisms
Type 2 diabetes
Unstable angina
Von Willebrand factor
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Summary:Objective von Willbrand factor antigen level (vWF: Ag) was shown to contribute to the risk of cardiovascular disease. vWF Thr789Ala single nucleotide polymorphism was thought to affect the factor level and function. This study aimed to investigate the impact of genetic variants at that position on the risk of acute coronary syndrome (ACS). Patients and methods The study included 112 patients of ACS; 31 with unstable angina (UA) and 81 with myocardial infarction (MI) as well as 118 healthy controls. vWF: Ag level was measured by enzyme-linked immunosorbent assay. The gene analysis was carried out by PCR using restriction fragment length polymorphism principles. Results vWF: Ag levels were significantly higher in patients (111.29±24.43 IU/dl) compared to the controls (71.13±13.72 IU/dl, P
ISSN:1110-1067
2090-9268
DOI:10.4103/ejh.ejh_8_17