Polymorphisms in IL-10 and TGF-[beta] gene promoter are associated with lower risk to gastric cancer in a Mexican population

Background Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network and inducing chronic inflammation. This work aimed to evaluate the associatio...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2019-05, Vol.19 (1)
Main Authors: Martínez-Campos, Cecilia, Torres-Poveda, Kirvis, Camorlinga-Ponce, Margarita, Flores-Luna, Lourdes, Maldonado-Bernal, Carmen, Madrid-Marina, Vicente, Torres, Javier
Format: Article
Language:English
Subjects:
Analysis
Bone morphogenetic proteins
Cancer
Cancer genetics
Chromosomes
Cytokines
DNA
Genes
Genetic aspects
Genetic polymorphisms
Genotypes
Helicobacter infections
Helicobacter pylori
Immune system
Infection
Inflammation
Risk factors
Single nucleotide polymorphisms
Stomach cancer
Transforming growth factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network and inducing chronic inflammation. This work aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in selected cytokine gene promoters and GC. Methods The study included 359 subjects, 125 GC patients, 109 intestinal metaplasia (IM) patients and 125 asymptomatic controls. DNA was extracted from white blood cells and nine SNPs in cytokine gene promoters were genotyped using predesigned 5'-endonulease assays. The association of the SNPs with IM and GC was evaluated using multinomial regression models. Results Both genotypes, TC (OR = 0.51, 95% CI = 0.27-0.98) and TT (OR = 0.42, 95% CI = 0.20-0.91) in the locus - 509 of the TGF-[beta] promoter were significantly associated with GC. The TT genotype in the locus - 819 of the IL-10 promoter was also significantly associated with GC (OR = 0.37, 95% CI = 0.17-0.81). No significant association was found with SNPs IL-4 -590 T/C (rs1800629), IL-6 -573G/C (rs1800796), IL-10 -592C/A (rs1800872), IL-10 -1082A/G (rs1800896), and, IFN-[gamma] -1615C/T (rs2069705). Conclusions SNPs in TGF[beta] (- 509 C/T, rs1800469) and IL-10 (- 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population. Keywords: Single nucleotide polymorphism, Cytokines, H, Pylori, Gastric cancer
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-019-5627-z