Insulin resistance in androgenetic alopecia and acne vulgaris

Background Insulin resistance (IR) is the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population. Some conditions strongly associated with IR such as acanthosis nigricans, acne, and psoria...

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Published in:Egyptian journal of dermatology and venereology 2019-07, Vol.39 (2), p.83-88
Main Authors: Abdelmawla, M, Esawy, Abdulla, Khater, Elsayed, Khalifa, Naglaa
Format: Article
Language:English
Subjects:
Acanthosis nigricans
Acne
Alopecia
Complications and side effects
Glucose
Glucose metabolism
Hirsutism
Insulin resistance
Physiological aspects
Psoriasis
Risk factors
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Summary:Background Insulin resistance (IR) is the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population. Some conditions strongly associated with IR such as acanthosis nigricans, acne, and psoriasis. Some conditions potentially associated with IR such as androgenetic alopecia (AGA), hirsutism, and hyperandrogenism. Some conditions anecdotally linked to IR such as alopecia areata and vitiligo. We aimed to analyze the relationship between IR and AGA and acne vulgaris, in comparison to controls. Patients and methods The study was carried out on 54 AGA and 54 acne vulgaris patients selected from Dermatology, and Venereology Department, Zagazig University Hospitals, 54 volunteers as a control, general, and dermatological examination were done. IR was estimated by the Homeostasis Model Assessment of Insulin Resistance. Results Statistically no significant differences between cases and control regarding sociodemographic distribution, blood glucose, and insulin. Nonsignificant differences between AGA and acne groups regarding sociodemographic distribution and duration of the disease. Nonsignificant differences between AGA and acne regarding blood glucose and insulin. Conclusion There is a role of insulin in the etiopathogenesis of AGA and acne.
ISSN:1110-6530
2314-7407
DOI:10.4103/ejdv.ejdv_28_18