Simple Virilization Type of Classic Congenital Adrenal Hyperplasia: Case Report

We have reported a case of 21 year old patient with congenital adrenal hyperplasia that manifestated with ambiguous genitalia and other signs of androgen excess. Chromosome analysis revealed 46 XX. Laboratory examination and imaging showed high level of 17-hydroxyprogesterone, undeveloped uterus, tw...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2018-09, Vol.11 (3), p.1345-1350
Main Authors: Dwipayana, Pande, Sudjana, Karismayusa, Semadi, Siswadi, Suastika, Ketut, Saraswati, Ratna, Gotera, Wira
Format: Article
Language:English
Subjects:
Androgens
Care and treatment
Congenital adrenal hyperplasia
Diagnosis
Fludrocortisone
Genetic disorders
Genetic research
Genitalia
Glucocorticoids
Hydroxyprogesterone
Hyperplasia
Surgery
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Summary:We have reported a case of 21 year old patient with congenital adrenal hyperplasia that manifestated with ambiguous genitalia and other signs of androgen excess. Chromosome analysis revealed 46 XX. Laboratory examination and imaging showed high level of 17-hydroxyprogesterone, undeveloped uterus, two ovaries with follicles, no testicles, no prostate, and mass at upper side of both kidney with irregular border confirmed the diagnosis. It was planned to give glucocorticoid therapy to the patient to suppress androgen level, genital reconstruction surgery and psychosexual therapy to reared as a woman, but she refused all suggestions because she wanted to be considered a man.
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/1497