Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with [beta]S haplotype and [alpha]-thalassemia

This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with [beta].sup.S haplotype and [alpha]-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 mo...

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Published in:PloS one 2019-07, Vol.14 (7), p.e0218040
Main Authors: Yahouédéhou, Sètondji Cocou Modeste Alexandre, da Guarda, Caroline Conceição, Figueiredo, Camylla Vilas Boas, Santiago, Rayra Pereira, Carvalho, Suellen Pinheiro, Fiuza, Luciana Magalhães, Ndidi, Uche Samuel, Oliveira, Rodrigo Mota, Carvalho, Magda Oliveira Seixas, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Lyra, Isa Menezes, Adorno, Elisângela Vitória, Goncalves, Marilda Souza
Format: Article
Language:English
Subjects:
Albumin
Analysis
Anemia
Bilirubin
Biochemistry
Biological markers
Care and treatment
Child health
Children
Glucose
Glycosylated hemoglobin
Hemoglobins
Hydroxyurea
Life expectancy
Lymphocytes
Medical research
Purines
Sickle cell anemia
Thalassemia
Triglycerides
Uric acid
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Summary:This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with [beta].sup.S haplotype and [alpha]-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0218040