A Comparative Study of the Biocompatibility of Two Root-End Filling Materials in Rat Connective Tissue/Estudio Comparativo de la Biocompatibilidad de Dos Materiales de Retro-Obturacion en Tejido Conectivo de Rata

• Published in: International journal of morphology 2019-09, Vol.37 (3), p.792
• Main Authors: Cantú, Francisco Javier Gutiérrez, Zamora, Guadalupe Magaña, Rodríguez, Ricardo Oliva, Cortes, José Obed García, Meraz, Wulfrano Sánchez, Cárdenas, Jairo Mariel
• Format: Article
• Language: Spanish
• ISSN: 0717-9367

The aim of the present study was to examine the short-term biocompatibility of Endosequence Root Repair Material (ERRM) paste and white Mineral Trioxide Aggregate MTA by implanting them into polyethylene tubes in the subcutaneous connective tissue of rats. twenty five male Wistar rats, 3-4 months old, weighing 300-350 g, were used. The tubes were implanted dorsally into the subcutaneous connective tissues of the rats. Five animals were sacrificed at five examination time points: 1, 3, 5, 1 and 15 days. The connective tissues containing the implants were excised. These sections were studied qualitatively and quantitatively using a light microscope. An average value for each group was obtained by averaging the sum of all inflammatory cells counted in 10 randomly selected, separate areas. For the ERRM group: There was a significant increase in the number of inflammatory cells on days 1-3 and on days 5-1 (P [less than or equal to] 0.003 and P [less than or equal to] 0.024). In the WHITE MTA group, the mean values of the sum of the inflammatory cells during the periods 1-3 days and 5-1 days were statistically significant (P [less than or equal to] 0.001 and P [less than or equal to] 0.044, respectively) and the XILOPERCHA group: Difference was observed significant in the value of the sum of inflammatory cells during the period of 3-5 days (P [less than or equal to] 0.05). According to the results it can be concluded that both, ERRM as MTA, caused an inflammatory reaction, which decreased over time; suggesting that both materials are biocompatible; showing however the presence of a higher organization of collagen fibers around the implants of ERRM. KEY WORDS: Restorative materials; White MTA; Biocompatibility; ERRM.