Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia

We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-02, Vol.166 (4), p.507
Main Authors: Nizyaeva, N.V, Kulikova, G.V, Nagovitsyna, M.N, Shchegolev, A.I
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Development and progression
Endothelium
Monoclonal antibodies
Preeclampsia
Pregnancy
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Summary:We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p
ISSN:0007-4888
DOI:10.1007/s10517-019-04383-6