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Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia
We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoc...
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Published in: | Bulletin of experimental biology and medicine 2019-02, Vol.166 (4), p.507 |
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creator | Nizyaeva, N.V Kulikova, G.V Nagovitsyna, M.N Shchegolev, A.I |
description | We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p |
doi_str_mv | 10.1007/s10517-019-04383-6 |
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Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p<0.05). The expression of TLR4 in syncytiotrophoblast and in the endothelium in early preeclampsia was also significantly (p<0.00001) higher than in the reference group (preterm birth before 34 weeks gestation). In the vascular endothelium of placental villi, the expression of TLR4 in placentas from women with early-onset preeclampsia was higher than in late-onset preeclampsia (p=0.002), while Tollip was lower in early-onset preeclampsia than in the reference group. In preeclampsia, especially in early-onset preeclampsia, marked changes in the expression of TLR4 and Tollip in the placental tissue were detected; the severity of preeclampsia correlated with the degree of damage to the placental villi. Key Words: pregnancy; placenta; early preeclampsia; TLR4; Tollip</description><identifier>ISSN: 0007-4888</identifier><identifier>DOI: 10.1007/s10517-019-04383-6</identifier><language>eng</language><publisher>Springer</publisher><subject>Analysis ; Antibodies ; Development and progression ; Endothelium ; Monoclonal antibodies ; Preeclampsia ; Pregnancy</subject><ispartof>Bulletin of experimental biology and medicine, 2019-02, Vol.166 (4), p.507</ispartof><rights>COPYRIGHT 2019 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Nizyaeva, N.V</creatorcontrib><creatorcontrib>Kulikova, G.V</creatorcontrib><creatorcontrib>Nagovitsyna, M.N</creatorcontrib><creatorcontrib>Shchegolev, A.I</creatorcontrib><title>Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia</title><title>Bulletin of experimental biology and medicine</title><description>We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p<0.05). The expression of TLR4 in syncytiotrophoblast and in the endothelium in early preeclampsia was also significantly (p<0.00001) higher than in the reference group (preterm birth before 34 weeks gestation). In the vascular endothelium of placental villi, the expression of TLR4 in placentas from women with early-onset preeclampsia was higher than in late-onset preeclampsia (p=0.002), while Tollip was lower in early-onset preeclampsia than in the reference group. In preeclampsia, especially in early-onset preeclampsia, marked changes in the expression of TLR4 and Tollip in the placental tissue were detected; the severity of preeclampsia correlated with the degree of damage to the placental villi. Key Words: pregnancy; placenta; early preeclampsia; TLR4; Tollip</description><subject>Analysis</subject><subject>Antibodies</subject><subject>Development and progression</subject><subject>Endothelium</subject><subject>Monoclonal antibodies</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><issn>0007-4888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkEFLw0AQhfegYK3-AU8BwdvW3ewm2RxLqVoItEjuZbI7aVa2ScluQY_-c5PaQwVPw3vzvoF5hDxwNuOMZc-es4RnlPGcMimUoOkVmbBhQ6VS6obcev8xSpbyCfneoD46C70NFn3U1VFoMFp-Hnr03nbt6JTFu4ygNdGqbWxlQ9efXboAr8FgVHbO2UNk2xO9caCxDTDqJfTui57oAgLSdesxRJseUTvYH7yFO3Jdg_N4f55TUr4sy8UbLdavq8W8oLtcKcpNamQMOjdCA5fKiDzJctBScsximVZ5KnJTcZ2YpOamZmh4BTzWSrBYChRT8vh7dgcOt7atu9CD3luvt_Mkl4IrNnQ1JbN_UjA-ube6a7G2g_8HeLoAGgQXGt-5Yxi685fBHypre9A</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Nizyaeva, N.V</creator><creator>Kulikova, G.V</creator><creator>Nagovitsyna, M.N</creator><creator>Shchegolev, A.I</creator><general>Springer</general><scope/></search><sort><creationdate>20190201</creationdate><title>Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia</title><author>Nizyaeva, N.V ; Kulikova, G.V ; Nagovitsyna, M.N ; Shchegolev, A.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g988-1d6d42ac9d3ca148d39579ac441e7246b9639db1c5d5f1df0ed1ba12c830243e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Antibodies</topic><topic>Development and progression</topic><topic>Endothelium</topic><topic>Monoclonal antibodies</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nizyaeva, N.V</creatorcontrib><creatorcontrib>Kulikova, G.V</creatorcontrib><creatorcontrib>Nagovitsyna, M.N</creatorcontrib><creatorcontrib>Shchegolev, A.I</creatorcontrib><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nizyaeva, N.V</au><au>Kulikova, G.V</au><au>Nagovitsyna, M.N</au><au>Shchegolev, A.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><date>2019-02-01</date><risdate>2019</risdate><volume>166</volume><issue>4</issue><spage>507</spage><pages>507-</pages><issn>0007-4888</issn><abstract>We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p<0.05). The expression of TLR4 in syncytiotrophoblast and in the endothelium in early preeclampsia was also significantly (p<0.00001) higher than in the reference group (preterm birth before 34 weeks gestation). In the vascular endothelium of placental villi, the expression of TLR4 in placentas from women with early-onset preeclampsia was higher than in late-onset preeclampsia (p=0.002), while Tollip was lower in early-onset preeclampsia than in the reference group. In preeclampsia, especially in early-onset preeclampsia, marked changes in the expression of TLR4 and Tollip in the placental tissue were detected; the severity of preeclampsia correlated with the degree of damage to the placental villi. Key Words: pregnancy; placenta; early preeclampsia; TLR4; Tollip</abstract><pub>Springer</pub><doi>10.1007/s10517-019-04383-6</doi></addata></record> |
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subjects | Analysis Antibodies Development and progression Endothelium Monoclonal antibodies Preeclampsia Pregnancy |
title | Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Early- and Late-Onset Preeclampsia |
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