Biological Surveying of Diverse Schiff Base Compounds: Antiproliferative, Antiradical and Enzyme Inhibition Activity

• Published in: Pharmaceutical chemistry journal 2019-07, Vol.53 (4), p.302-311
• Main Authors: Pasa, Salih, Tuneg, Muhammed, Boga, Mehmet
• Format: Article
• Language: English
• Subjects: Amino acids; Comparative analysis; Enzymes; Medicine; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Schiff bases; Terephthalic acid
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-019-01997-y

Schiff base compounds (((1Z,1 ′ Z)-(((ethane-1,2-diylbis(sulfanediyl))bis(2,1-phenylene))bis(azanylylidene)) bis(methanylylidene)) bis(4,1-phenylene))diboronic acid ( 1 ), 1,1′-((1Z,1′Z)-([1,1′-biphenyl]-4,4′-diylbis( azanylylidene)) bis(methanylylidene)) bis(naphthalen-2-ol) ( 2 ), 4,4′-((1Z,1′Z)-([1,1′-biphenyl]-4,4′-diylbis(azanylylidene)) bis(methanylylidene)) bis(2-methoxy phenol) ( 3 ), (N 4 Z,N 4 ′Z)-N 4 ,N 4 ′-bis(4-(dimethyl amino) benzylidene)-[1,1′-biphenyl]-4,4′-diamine ( 4 ), (E)-2-((2-hydroxybenzylidene)amino) terephthalic acid ( 5 ), and (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)terephthalic acid ( 6 ) have been synthesized. The structural identification was confirmed by spectroscopic techniques. The antiproliferative, antiradical, and enzyme activities were investigated in biological experimen0ts. The obtained results showed that Schiff base compounds 1 – 6 exhibited meaningful features in various biological tests. A comparison of compound 1 (containing boron atom in the structure) to compounds 2 – 6 shows that the inclusion of boron in the Schiff base determines whether this would increase or not the efficiency in biological experiments. Hereby, compound 1 exhibited significantly different results in all applications.