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Distribution of OXA-Type Carbapenemase Genes in Carbapenem-Resistant Acinetobacter baumannii Strains: An Investigation by Real-Time Polymerase Chain Reaction Method/ Karbapeneme Direncli Acinetobacter baumannii Suslarinda OXA Tipi Karbapenemaz Genlerinin Dagiliminin Gercek Zamanli Polimeraz Zincir Reaksiyonu Yontemiyle Incelenmesi
Amac: Karbapenemler, Acinetobacter baumannii infeksiyonlarinin tedavisinde kullanilan en onemli genis spektrumlu antibiyotiklerdir. Fakat dunya genelinde karbapenemlere direnc gittikce artmaktadir. Bu calismamizda, karbapenem direnci saptanan A. baumannii suslarinda gozlenen OXA tipi karbapenemaz ge...
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| Published in: | KLIMIK dergisi 2019-08, Vol.32 (2), p.123 |
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| creator | Demirci, Mehmet Yigin, Akin Demir, Cemil |
| description | Amac: Karbapenemler, Acinetobacter baumannii infeksiyonlarinin tedavisinde kullanilan en onemli genis spektrumlu antibiyotiklerdir. Fakat dunya genelinde karbapenemlere direnc gittikce artmaktadir. Bu calismamizda, karbapenem direnci saptanan A. baumannii suslarinda gozlenen OXA tipi karbapenemaz genlerinin dagilimini, gercek zamanli polimeraz zincir reaksiyonu (PCR) yontemiyle incelemeyi ve epidemiyolojik veri sunmayi amacladik. Yontemler: Ocak 2016-Ocak 2018 arasinda klinik orneklerden izole edilen karbapeneme direncli 20 A. baumannii susu calismaya dahil edildi. Bu suslardan DNA izolasyonlari gerceklestirildi ve OXA-23, OXA-24, OXA-51 ve OXA-58 karbapenemazlarinin genlerine spesifik primer ve TaqMan problari kullanilarak gercek zamanli PCR yontemiyle OXA karbapenemaz genlerinin dagilimi incelendi. Bulgular: Karbapeneme direncli A. baumannii suslarinin 16 (%80)'sinin duyarli oldugu tigesiklin bu suslara bagli infeksiyonlar icin en iyi secenekti. Tum suslarda [bla.sub.OXA-51] saptanirken, [bla.sub.OXA-24] sadece 1 (%5) susta saptandi. Yirmi sustan 10 (%50)'unda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteligi vardi. Sonuclar: Karbapeneme direncli A. baumannii suslarindaki OXA tipi karbapenemazlarin dagiliminda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteliginin daha sik olmasi dikkati cekmistir. Gercek zamanli PCR gibi hizli ve guvenilir sonuc verebilecek tekniklerle, boyle direncli suslarin rutin surveyanslari yapildiginda degerli epidemiyolojik veriler elde edilebilir. Klimik Dergisi 2019; 32(2): 123-6. Anahtar Sozcukler: Acinetobacter baumannii, OXA tipi karbapenemaz, gercek zamanli polimeraz zincir reaksiyonu. Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant |
| doi_str_mv | 10.5152/kd.2019.29 |
| format | article |
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Fakat dunya genelinde karbapenemlere direnc gittikce artmaktadir. Bu calismamizda, karbapenem direnci saptanan A. baumannii suslarinda gozlenen OXA tipi karbapenemaz genlerinin dagilimini, gercek zamanli polimeraz zincir reaksiyonu (PCR) yontemiyle incelemeyi ve epidemiyolojik veri sunmayi amacladik. Yontemler: Ocak 2016-Ocak 2018 arasinda klinik orneklerden izole edilen karbapeneme direncli 20 A. baumannii susu calismaya dahil edildi. Bu suslardan DNA izolasyonlari gerceklestirildi ve OXA-23, OXA-24, OXA-51 ve OXA-58 karbapenemazlarinin genlerine spesifik primer ve TaqMan problari kullanilarak gercek zamanli PCR yontemiyle OXA karbapenemaz genlerinin dagilimi incelendi. Bulgular: Karbapeneme direncli A. baumannii suslarinin 16 (%80)'sinin duyarli oldugu tigesiklin bu suslara bagli infeksiyonlar icin en iyi secenekti. Tum suslarda [bla.sub.OXA-51] saptanirken, [bla.sub.OXA-24] sadece 1 (%5) susta saptandi. Yirmi sustan 10 (%50)'unda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteligi vardi. Sonuclar: Karbapeneme direncli A. baumannii suslarindaki OXA tipi karbapenemazlarin dagiliminda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteliginin daha sik olmasi dikkati cekmistir. Gercek zamanli PCR gibi hizli ve guvenilir sonuc verebilecek tekniklerle, boyle direncli suslarin rutin surveyanslari yapildiginda degerli epidemiyolojik veriler elde edilebilir. Klimik Dergisi 2019; 32(2): 123-6. Anahtar Sozcukler: Acinetobacter baumannii, OXA tipi karbapenemaz, gercek zamanli polimeraz zincir reaksiyonu. Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. [Bla.sub.OXA-51] was detected in all strains, while [bla.sub.OXA-24] was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of [bla.sub.OXA-23] and [bla.sub.OXA-51] simultaneously. Conclusions: Simultaneous occurence of [bla.sub.OXA-23] and [bla.sub.OXA-51] is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR. Klimik Dergisi 2019; 32(2): 123-6. Key Words: Acinetobacter baumannii, OXA-type carbapenemase, real-time polymerase chain reaction.</description><identifier>ISSN: 1301-143X</identifier><identifier>DOI: 10.5152/kd.2019.29</identifier><language>eng</language><publisher>AVES</publisher><subject>Anopheles ; Beta lactamases ; DNA ; Epidemiology ; Genes ; Genetic research ; Imipenem ; Meropenem ; Oxalic acid ; Polymerase chain reaction ; Rutin ; Tigecycline</subject><ispartof>KLIMIK dergisi, 2019-08, Vol.32 (2), p.123</ispartof><rights>COPYRIGHT 2019 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Demirci, Mehmet</creatorcontrib><creatorcontrib>Yigin, Akin</creatorcontrib><creatorcontrib>Demir, Cemil</creatorcontrib><title>Distribution of OXA-Type Carbapenemase Genes in Carbapenem-Resistant Acinetobacter baumannii Strains: An Investigation by Real-Time Polymerase Chain Reaction Method/ Karbapeneme Direncli Acinetobacter baumannii Suslarinda OXA Tipi Karbapenemaz Genlerinin Dagiliminin Gercek Zamanli Polimeraz Zincir Reaksiyonu Yontemiyle Incelenmesi</title><title>KLIMIK dergisi</title><description>Amac: Karbapenemler, Acinetobacter baumannii infeksiyonlarinin tedavisinde kullanilan en onemli genis spektrumlu antibiyotiklerdir. Fakat dunya genelinde karbapenemlere direnc gittikce artmaktadir. Bu calismamizda, karbapenem direnci saptanan A. baumannii suslarinda gozlenen OXA tipi karbapenemaz genlerinin dagilimini, gercek zamanli polimeraz zincir reaksiyonu (PCR) yontemiyle incelemeyi ve epidemiyolojik veri sunmayi amacladik. Yontemler: Ocak 2016-Ocak 2018 arasinda klinik orneklerden izole edilen karbapeneme direncli 20 A. baumannii susu calismaya dahil edildi. Bu suslardan DNA izolasyonlari gerceklestirildi ve OXA-23, OXA-24, OXA-51 ve OXA-58 karbapenemazlarinin genlerine spesifik primer ve TaqMan problari kullanilarak gercek zamanli PCR yontemiyle OXA karbapenemaz genlerinin dagilimi incelendi. Bulgular: Karbapeneme direncli A. baumannii suslarinin 16 (%80)'sinin duyarli oldugu tigesiklin bu suslara bagli infeksiyonlar icin en iyi secenekti. Tum suslarda [bla.sub.OXA-51] saptanirken, [bla.sub.OXA-24] sadece 1 (%5) susta saptandi. Yirmi sustan 10 (%50)'unda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteligi vardi. Sonuclar: Karbapeneme direncli A. baumannii suslarindaki OXA tipi karbapenemazlarin dagiliminda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteliginin daha sik olmasi dikkati cekmistir. Gercek zamanli PCR gibi hizli ve guvenilir sonuc verebilecek tekniklerle, boyle direncli suslarin rutin surveyanslari yapildiginda degerli epidemiyolojik veriler elde edilebilir. Klimik Dergisi 2019; 32(2): 123-6. Anahtar Sozcukler: Acinetobacter baumannii, OXA tipi karbapenemaz, gercek zamanli polimeraz zincir reaksiyonu. Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. [Bla.sub.OXA-51] was detected in all strains, while [bla.sub.OXA-24] was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of [bla.sub.OXA-23] and [bla.sub.OXA-51] simultaneously. Conclusions: Simultaneous occurence of [bla.sub.OXA-23] and [bla.sub.OXA-51] is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR. Klimik Dergisi 2019; 32(2): 123-6. Key Words: Acinetobacter baumannii, OXA-type carbapenemase, real-time polymerase chain reaction.</description><subject>Anopheles</subject><subject>Beta lactamases</subject><subject>DNA</subject><subject>Epidemiology</subject><subject>Genes</subject><subject>Genetic research</subject><subject>Imipenem</subject><subject>Meropenem</subject><subject>Oxalic acid</subject><subject>Polymerase chain reaction</subject><subject>Rutin</subject><subject>Tigecycline</subject><issn>1301-143X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNp1UcFu2zAM9YANWNH10i8QsLNTyY5jezcj2bJiGTq0PrS9FLREp1xkKZCUAe7XT06HIYdNPIigHt97pJLkUvBZIYrsaqdmGRf1LKvfJmci5yIV8_z-fXLh_U8-nZKX8-LszWZFPjjqDoGsYbZnN_dN2o57ZEtwHezR4AAe2TomnpE5Kae36GMzmMAaSQaD7UAGdKyDwwDGELG74ICM_8Qaw67NL_SBtnBU6kZ2i6DTlgZkP6weB3STzvI5NkxP8gj7juHZqiv27a8qshU5NFLT_1UPXoMjo2CahrW0pxMCeJmG0RgBUWkFW9I0HPM1Ook79giRJ9JHVzS5emGPZCS5ydXO02jNgT1YE3CgUWOcS6JGM8RlfEje9aA9Xvy5z5P2y-d2-TXd3Kyvl80m3S7KIhVYKA5KAvQq_lFXSdFJlUGuqlzwPKt7Ma-FyisUXdnJHBVWXEBZLjiKqsry8-TjK-0WND6R6W1csxzIy6dmwXktFlVVRNTsH6gYKhqX1mBPsX7S8Bu-f7tq</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Demirci, Mehmet</creator><creator>Yigin, Akin</creator><creator>Demir, Cemil</creator><general>AVES</general><scope/></search><sort><creationdate>20190801</creationdate><title>Distribution of OXA-Type Carbapenemase Genes in Carbapenem-Resistant Acinetobacter baumannii Strains: An Investigation by Real-Time Polymerase Chain Reaction Method/ Karbapeneme Direncli Acinetobacter baumannii Suslarinda OXA Tipi Karbapenemaz Genlerinin Dagiliminin Gercek Zamanli Polimeraz Zincir Reaksiyonu Yontemiyle Incelenmesi</title><author>Demirci, Mehmet ; Yigin, Akin ; Demir, Cemil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g675-1e5d0adcaafd201b8c1bcd2a3d8310329f1491d38e1b7bc3ede801a7760e18823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anopheles</topic><topic>Beta lactamases</topic><topic>DNA</topic><topic>Epidemiology</topic><topic>Genes</topic><topic>Genetic research</topic><topic>Imipenem</topic><topic>Meropenem</topic><topic>Oxalic acid</topic><topic>Polymerase chain reaction</topic><topic>Rutin</topic><topic>Tigecycline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demirci, Mehmet</creatorcontrib><creatorcontrib>Yigin, Akin</creatorcontrib><creatorcontrib>Demir, Cemil</creatorcontrib><jtitle>KLIMIK dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demirci, Mehmet</au><au>Yigin, Akin</au><au>Demir, Cemil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of OXA-Type Carbapenemase Genes in Carbapenem-Resistant Acinetobacter baumannii Strains: An Investigation by Real-Time Polymerase Chain Reaction Method/ Karbapeneme Direncli Acinetobacter baumannii Suslarinda OXA Tipi Karbapenemaz Genlerinin Dagiliminin Gercek Zamanli Polimeraz Zincir Reaksiyonu Yontemiyle Incelenmesi</atitle><jtitle>KLIMIK dergisi</jtitle><date>2019-08-01</date><risdate>2019</risdate><volume>32</volume><issue>2</issue><spage>123</spage><pages>123-</pages><issn>1301-143X</issn><abstract>Amac: Karbapenemler, Acinetobacter baumannii infeksiyonlarinin tedavisinde kullanilan en onemli genis spektrumlu antibiyotiklerdir. Fakat dunya genelinde karbapenemlere direnc gittikce artmaktadir. Bu calismamizda, karbapenem direnci saptanan A. baumannii suslarinda gozlenen OXA tipi karbapenemaz genlerinin dagilimini, gercek zamanli polimeraz zincir reaksiyonu (PCR) yontemiyle incelemeyi ve epidemiyolojik veri sunmayi amacladik. Yontemler: Ocak 2016-Ocak 2018 arasinda klinik orneklerden izole edilen karbapeneme direncli 20 A. baumannii susu calismaya dahil edildi. Bu suslardan DNA izolasyonlari gerceklestirildi ve OXA-23, OXA-24, OXA-51 ve OXA-58 karbapenemazlarinin genlerine spesifik primer ve TaqMan problari kullanilarak gercek zamanli PCR yontemiyle OXA karbapenemaz genlerinin dagilimi incelendi. Bulgular: Karbapeneme direncli A. baumannii suslarinin 16 (%80)'sinin duyarli oldugu tigesiklin bu suslara bagli infeksiyonlar icin en iyi secenekti. Tum suslarda [bla.sub.OXA-51] saptanirken, [bla.sub.OXA-24] sadece 1 (%5) susta saptandi. Yirmi sustan 10 (%50)'unda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteligi vardi. Sonuclar: Karbapeneme direncli A. baumannii suslarindaki OXA tipi karbapenemazlarin dagiliminda [bla.sub.OXA-23] ve [bla.sub.OXA-51] birlikteliginin daha sik olmasi dikkati cekmistir. Gercek zamanli PCR gibi hizli ve guvenilir sonuc verebilecek tekniklerle, boyle direncli suslarin rutin surveyanslari yapildiginda degerli epidemiyolojik veriler elde edilebilir. Klimik Dergisi 2019; 32(2): 123-6. Anahtar Sozcukler: Acinetobacter baumannii, OXA tipi karbapenemaz, gercek zamanli polimeraz zincir reaksiyonu. Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. [Bla.sub.OXA-51] was detected in all strains, while [bla.sub.OXA-24] was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of [bla.sub.OXA-23] and [bla.sub.OXA-51] simultaneously. Conclusions: Simultaneous occurence of [bla.sub.OXA-23] and [bla.sub.OXA-51] is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR. Klimik Dergisi 2019; 32(2): 123-6. Key Words: Acinetobacter baumannii, OXA-type carbapenemase, real-time polymerase chain reaction.</abstract><pub>AVES</pub><doi>10.5152/kd.2019.29</doi></addata></record> |
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| subjects | Anopheles Beta lactamases DNA Epidemiology Genes Genetic research Imipenem Meropenem Oxalic acid Polymerase chain reaction Rutin Tigecycline |
| title | Distribution of OXA-Type Carbapenemase Genes in Carbapenem-Resistant Acinetobacter baumannii Strains: An Investigation by Real-Time Polymerase Chain Reaction Method/ Karbapeneme Direncli Acinetobacter baumannii Suslarinda OXA Tipi Karbapenemaz Genlerinin Dagiliminin Gercek Zamanli Polimeraz Zincir Reaksiyonu Yontemiyle Incelenmesi |
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