Potentiometric Sensor for Benzylpenicillin Determination

A potentiometric benzylpenicillin-sensitive sensor with a plasticized polyvinyl-chloride membrane was developed. The sensor contains a benzylpenicillin—rhodamine 6G ion pair. The response is linear for benzylpenicillin concentrations in the range 10 –3 – 10 –1 M with an electrode-function slope char...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2019-09, Vol.53 (6), p.577-579
Main Authors: Kormosh, Zh. A., Markovska, N. A., Kormosh, N. N.
Format: Article
Language:English
Subjects:
Medicine
Methods of Analysis and Process Control
Organic Chemistry
Penicillin G
Pharmacology/Toxicology
Pharmacy
Sensors
Structure of Chemical Compounds
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Summary:A potentiometric benzylpenicillin-sensitive sensor with a plasticized polyvinyl-chloride membrane was developed. The sensor contains a benzylpenicillin—rhodamine 6G ion pair. The response is linear for benzylpenicillin concentrations in the range 10 –3 – 10 –1 M with an electrode-function slope characteristic of singly charged anions and a minimum detected concentration of (6.3 – 7.9) × 10 –4 M. This sensor could be used to detect and determine benzylpenicillin in pharmaceuticals.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02040-w