Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs

A series of N 1 , N 3 - bis -hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2019-09, Vol.53 (6), p.511-515
Main Authors: Brel’, A. K., Spasov, A. A., Lisina, S. V., Popov, S. S., Kucheryavenko, A. F., Litvinov, R. A., Salaznikova, O. A., Rashchenko, A. I.
Format: Article
Language:English
Subjects:
Hypoglycemic agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyrimidines
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Summary:A series of N 1 , N 3 - bis -hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological treatment of thrombosis and angio-, nephro-, encephalo-, and cardiopathies. 1,3- bis -(4-Methoxybenzoyl)pyrimidine-2,4(1 H ,3 H )-dione was a promising antidiabetic agent with all studied activities.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02029-5