Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs

A series of N 1 , N 3 - bis -hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological...

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Published in:Pharmaceutical chemistry journal 2019-09, Vol.53 (6), p.511-515
Main Authors: Brel’, A. K., Spasov, A. A., Lisina, S. V., Popov, S. S., Kucheryavenko, A. F., Litvinov, R. A., Salaznikova, O. A., Rashchenko, A. I.
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Language:English
Subjects:
Hypoglycemic agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyrimidines
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creator Brel’, A. K.
Spasov, A. A.
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Rashchenko, A. I.
description A series of N 1 , N 3 - bis -hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, which are most significant for pharmacological treatment of thrombosis and angio-, nephro-, encephalo-, and cardiopathies. 1,3- bis -(4-Methoxybenzoyl)pyrimidine-2,4(1 H ,3 H )-dione was a promising antidiabetic agent with all studied activities.
doi_str_mv 10.1007/s11094-019-02029-5
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subjects Hypoglycemic agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyrimidines
title Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs
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