Assessment of the Wound-Healing Action of Spiroconjugated 1,2,3-Triazolo[5,1-b]-1,3,4-Thiadiazine in a Linear Skin Wound Model

The effects of the 5′-(4-ethoxybenzoyl)-5′,7′-dihydrospiro[cyclopentane-1,6′-[1,2,3]-triazolo[5,1- b ][1,3,4]-thiadiazine]-3′-carboxylic acid ethyl ester oon the healing of linear skin wounds were studied in rats. This compound was found to have a stimulatory action on skin fibroblast proliferation,...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2019-10, Vol.53 (7), p.642-645
Main Authors: Vysokova, O. A., Zhdanova, A. V., Petrova, I. M., Medvedeva, S. Yu, Kalinina, T. A., Khatsko, S. L., Kolesnikova, T. O., Glukhareva, T. V., Morzherin, Yu. Yu
Format: Article
Language:English
Subjects:
Analysis
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Skin
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Summary:The effects of the 5′-(4-ethoxybenzoyl)-5′,7′-dihydrospiro[cyclopentane-1,6′-[1,2,3]-triazolo[5,1- b ][1,3,4]-thiadiazine]-3′-carboxylic acid ethyl ester oon the healing of linear skin wounds were studied in rats. This compound was found to have a stimulatory action on skin fibroblast proliferation, increasing the regenerative potential of damaged tissue. Assessment of the course of the wound process showed that use of test substance clearly accelerated the course of repair regeneration of the integument as compared with controls; inflammatory processes were moderate, without involvement of the deep layers of the skin; a cellular and fibrous component formed in the lesion zone.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02054-4