CATALYTIC ACTIVITY OF NICKEL FERRITE NANOPARTICLES IN SYNTHESIS OF 4-ARYL BENZELIDENE-2- -ONE AND ITS EVALUTE THE BIOLOGICAL ACTIVITY

Seven 4-arylbenzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one derivatives were synthesized by the condensation of 2-(2-(5-fluoro-1H-indol-1-yl) acetoamide) acetic acid, substituted aromatic aldehydes with acetic anhydride and sodium acetate in the presence of MgO/[Al.sub.2][O.sub.3] und...

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Published in:Bulletin of the Chemical Society of Ethiopia 2019-09, Vol.33 (3), p.517
Main Authors: Rao, Tentu Nageswara, Rao, N. Krishna, Parvatamma, Botsa, Devi, Velayudhan Kamala, Naidu, T. Manohra
Format: Article
Language:English
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Acetic acid
Amino acids
Iron compounds
Nanoparticles
Nickel (Metal)
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container_title Bulletin of the Chemical Society of Ethiopia
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Rao, N. Krishna
Parvatamma, Botsa
Devi, Velayudhan Kamala
Naidu, T. Manohra
description Seven 4-arylbenzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one derivatives were synthesized by the condensation of 2-(2-(5-fluoro-1H-indol-1-yl) acetoamide) acetic acid, substituted aromatic aldehydes with acetic anhydride and sodium acetate in the presence of MgO/[Al.sub.2][O.sub.3] under reflux using nickel ferrite nanoparticles. Seven of the compounds are new derivatives. 2-(2-(5-fluoro-1H-indol-1-yl)acetoamide) acetic acid was obtained from 2-(5-fluoro-1H-indol-1-yl)acetyl chloride with lysine in the presence of NaOH and HCl in the ice cold solution. 2-(5-fluoro-1H-indol-1-yl)acetyl chloride can be prepared from 5-fluoro indole with chloroacetyl chloride in triethylamine and dichloromethane. The structures of the compounds were evaluated based on 1H-NMR, [.sup.13]C-NMR and LC-MS and by elemental analysis. These compounds were screened by anti-oxidant as well as anti-microbial activity. KEY WORDS: 2-(5-Fluoro-1H-indol-1-yl)acetyl chloride, 2-(2-(5-Fluoro-1H-indol-1-yl)acetoamide) acetic acid, 4-Aryl Benzelidene-2-((5-fluoro-1H-indol-1-yl)methyl)oxazol-5(4H)-one, Anti-oxidant, Anti-microbial activity, Nickel ferrite
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subjects Acetic acid
Amino acids
Iron compounds
Nanoparticles
Nickel (Metal)
title CATALYTIC ACTIVITY OF NICKEL FERRITE NANOPARTICLES IN SYNTHESIS OF 4-ARYL BENZELIDENE-2- -ONE AND ITS EVALUTE THE BIOLOGICAL ACTIVITY
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