Effect of short-term, high-intensity exercise training on human skeletal muscle citrate synthase maximal activity: single versus multiple bouts per session

• Published in: Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2019-12, Vol.44 (12), p.1391-1394
• Main Authors: MacInnis, Martin J, Skelly, Lauren E, Godkin, F. Elizabeth, Martin, Brian J, Tripp, Thomas R, Tarnopolsky, Mark A, Gibala, Martin J
• Format: Article
• Language: English
• Subjects: Biopsy; Biopsy, Needle; Citrate (si)-Synthase - metabolism; durée de l’entraînement; Effects; entraînement par intervalles de haute intensité; exercice; Exercise; Fitness training programs; Glucose; high-intensity interval training; Humans; Male; Men; metabolism; Mitochondria, Muscle - metabolism; Muscles; Musculoskeletal system; métabolisme; Quadriceps Muscle - enzymology; Time Factors; training duration; training volume; unilateral; unilatéral; volume de l’entraînement; Young Adult
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/apnm-2019-0403

The legs of 9 men (age 21 ± 2 years, 45 ± 4 mL/(kg·min)) were randomly assigned to complete 6 sessions of high-intensity exercise training, involving either one or four 5-min bouts of counterweighted, single-leg cycling. Needle biopsies from vastus lateralis revealed that citrate synthase maximal activity increased after training in the 4-bout group (p = 0.035) but not the 1-bout group (p = 0.10), with a significant difference between groups post-training (13%, p = 0.021). Novelty Short-term training using brief intense exercise requires multiple bouts per session to increase mitochondrial content in human skeletal muscle.