The Effect of Erythropoiesis-Stimulating Agents on Platelet Aggregation in Peritoneal Dialysis Patients/Periton Diyaliz Hastalarinda Eritropoietin Stimule Eden Ajanlar Kullaniminin Trombosit Agregasyonu Uzerindeki Etkisi

Introduction: Erythropoietin (Epo) is a hormone that is synthesized in the kidneys and that stimulates the erythropoiesis in the bone marrow. Epo has effects apart from the erythropoiesis. In chronic renal failure (CRF) patients, hemorrhagic diathesis is observed, and Epo production is decreased. Er...

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Bibliographic Details
Published in:Istanbul medical journal 2019-11, Vol.20 (6), p.524
Main Authors: Bakirdogen, Serkan, Eren, Necmi, Bek, Sibel Gokcay, Yavuz, Sara
Format: Article
Language:eng ; tur
Subjects:
Anemia
Blood
Blood tests
Care and treatment
Chronic kidney failure
Erythropoietin
Glycoproteins
Glycosylated hemoglobin
Hemoglobin
Hemoglobins
Hormones
Kidney failure
Medical examination
Medical research
Medicine, Experimental
Transferrin
User groups
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Summary:Introduction: Erythropoietin (Epo) is a hormone that is synthesized in the kidneys and that stimulates the erythropoiesis in the bone marrow. Epo has effects apart from the erythropoiesis. In chronic renal failure (CRF) patients, hemorrhagic diathesis is observed, and Epo production is decreased. Erythropoiesis-stimulating agents (ESAs) are widely used in the treatment of renal anemia in these patients. Our study aimed to investigate the effect of ESAs use on platelet aggregation in peritoneal dialysis (PD) patients due to CRF. Methods: Forty-three PD patients were included in the study. Seventeen patients had been using ESAs for anemia for at least three months (ESAs user group). Twenty-six patients were not using ESAs since they did not have indications (non-ESAs user group). Platelet aggregation measurement from the whole blood was carried out in each patient by a multiplate device. The calculated values [area under the curve (AUC), aggregation, and velocity] were recorded. The results were evaluated statistically, and p
ISSN:2619-9793
1304-8503
DOI:10.4274/imj.galenos.2019.47048