Effect of Stimulation of [[alpha].sub.2]-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium

The study examined the effect of clonidine hydrochloride ([10.sup.-9]-[10.sup.-5] M) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of [[alpha].sub.2]-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agon...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-09, Vol.167 (5), p.603
Main Authors: Zefirov, T.L, Faskhutdinov, L.I, Ziyatdinova, N.I, Galieva, A.M, Zefirov, A.L
Format: Article
Language:English
Subjects:
Cardiology
Clonidine
Heart cells
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Summary:The study examined the effect of clonidine hydrochloride ([10.sup.-9]-[10.sup.-5] M) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of [[alpha].sub.2]-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of [10.sup.-5] M. Key Words: [[alpha].sub.2]-adrenergic receptor; clonidine; action potential; atrium; rat
ISSN:0007-4888
DOI:10.1007/s10517-019-04579-w