A safe fix for alcohol-derived DNA damage

A by-product of alcohol metabolism can damage the genome by crosslinking opposing DNA strands. The discovery of a safe mechanism that reverses such damage might open up avenues of research for drug discovery. A previously unknown mechanism for repairing DNA interstrand crosslinks.

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Bibliographic Details
Published in:Nature (London) 2020-03, Vol.579 (7800), p.499-500
Main Authors: Gallina, Irene, Duxin, Julien P.
Format: Article
Language:English
Subjects:
631/337
631/45
Acetaldehyde
Alcohol-related disorders
Care and treatment
Complications and side effects
Crosslinking
DNA
DNA Damage
DNA repair
Ethanol - toxicity
Genetic aspects
Genetic disorders
Genetic research
Health aspects
News And Views
Proteins
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Description
Summary:A by-product of alcohol metabolism can damage the genome by crosslinking opposing DNA strands. The discovery of a safe mechanism that reverses such damage might open up avenues of research for drug discovery. A previously unknown mechanism for repairing DNA interstrand crosslinks.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-020-00462-1