Antiproliferative Activity of 2-Aroyland 2-Heteroyl-1,1,3,3-Tetracyanoprop-2-en-1-ides

The influence of previously synthesized 2-aroyl-1,1,3,3-tetracyanoprop-2-en-1-ides on the growth of conditionally normal and tumor cells was studied in continuation of a search for new anticancer drugs. Cytotoxicities of the compounds were studied with respect to human tumor cell lines from the ATCC...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2020-05, Vol.54 (2), p.142-144
Main Authors: Mar’yasov, M. A., Kayukov, Ya. S., Nasakin, O. E.
Format: Article
Language:English
Subjects:
Cancer
Chemotherapy
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The influence of previously synthesized 2-aroyl-1,1,3,3-tetracyanoprop-2-en-1-ides on the growth of conditionally normal and tumor cells was studied in continuation of a search for new anticancer drugs. Cytotoxicities of the compounds were studied with respect to human tumor cell lines from the ATCC. All compounds were ineffective against melanoma and lung and ovary cancer cell lines and exhibited moderate activity in the other cases. The tested compounds exhibited highly selective effects because they were safe for conditionally normal skin fibroblasts.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02170-6