Protective Association of Single Nucleotide Polymorphisms rsl86l868-FTO and rs7975232-VDR and Obesity in Saudi Females

Background: Obesity is a major health threat worldwide. It predisposes individuals to diabetes, cardiovascular complications, and cancer. Genetic and environmental factors are responsible for the increasing incidence of obesity. In this study, we investigated the genetic factors associated with obes...

Full description

Saved in:
Bibliographic Details
Published in:International journal of general medicine 2020-05, p.235
Main Authors: Al Asoom, Lubna Ibrahim, Al Afandi, Dina Tariq, Al Abdulhadi, Aseel Salah, Rafique, Nazish, Chathoth, Shahanas, Al Sunni, Ahmad A
Format: Article
Language:English
Subjects:
Blood glucose
Body mass index
Body weight
Cholesterol
Chromosomes
Genetic aspects
Low density lipoproteins
Obesity
Scientific equipment industry
Single nucleotide polymorphisms
Type 2 diabetes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Obesity is a major health threat worldwide. It predisposes individuals to diabetes, cardiovascular complications, and cancer. Genetic and environmental factors are responsible for the increasing incidence of obesity. In this study, we investigated the genetic factors associated with obesity in young Saudi women. Subjects and Methods: In this cross-sectional study, 131 young Saudi female students were recruited. Body mass index (BMI), waist-hip ratio, blood glucose, triglyceride, cholesterol, HDL, LDL, and vitamin D3 levels of the subjects were determined. Twelve SNPs of different genes that showed a correlation with obesity in different population were tested, namely GNPDA2 (rs10938397), TCF7L2 (rs10885409), FTO (rs1477196), ADIPOQ (rs1501299), MC4R (rs17782313), ABCA1 (rs1800977), FTO (rs1861868), VDR (rs2228570), VDR (rs731236), VDR (rs7975232), ADIPOQ (rs266729), and PFPK (rs6602024). Student's t-test was conducted for all parameters. Pearson correlation was performed to identify the correlated variables. The frequencies of different risk alleles were determined by direct counting of the test allele divided by the total number ofalleles and compared. Results: Only two SNPs, rs1861868 of FTO and rs7975232 of VDR, of the twelve tested SNPs showed significant protective associations with the BMI with odds ratio 0.3886 (0.1761-0.8572); p 0.0192 and odds ratio 0.4563 (0.2343-0.8888); p 0.0211, respectively. Conclusion: The current study showed that minor alleles, "T" of FTO and "A" of VDR, might be protective factors against increased BMI in young Saudi female subjects. To elucidate this association, further studies with larger sample size involving both sexes are required. Keywords: BMI, obesity, body weight, FTO gene, VDR gene, polymorphism
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S251466