The association between Matrix Metallo-proteinases-9 : a systematic review and meta-analysis

Background We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). Methods After a systematic literature search, pooled odds ratio (OR) and their corr...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2020-05, Vol.20 (1)
Main Authors: Hassanzadeh-Makoui, Reza, Razi, Bahman, Aslani, Saeed, Imani, Danyal, Tabaee, Seyedeh Samaneh
Format: Article
Language:English
Subjects:
Coronary heart disease
Genetic aspects
Genetic polymorphisms
Health aspects
Metalloproteins
Risk factors
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Summary:Background We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). Methods After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association. Results We identified 40 studies with 11,792 cases and 8280 controls for C1562T, 7 case-control studies with 5525 cases and 2497 controls for R279Q, 2 studies with 1272 cases and 785 controls for P574R, and 2 studies with 1272 cases and 785 controls for R668Q. MMP-9 (C1562T) polymorphism was associated with increased risk of CAD under dominant model (OR = 1.41, P < 0.001), recessive model (OR = 1.59, P < 0.001), allelic model (OR = 1.38, P < 0.001), TT vs. CC model (OR = 1.70, P < 0.001), and CT vs. CC model (OR = 1.35, P < 0.001). Moreover, the subgroup analysis based on the continent of the study populations in this SNP indicated strong significant association in Asians but not in Europeans. Subgroup analysis was not performed in Africa, America and Oceania, due to lack of sufficient data. Conclusions Our meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population. The overall analysis and subgroup analysis of the other three SNPs reject the association between MMP-9 polymorphisms and the risk of CAD. Although the results should interpret with caution because of small sample size of included studies in these three SNPs. Keywords: Coronary artery disease, Matrix metalloproteinases, Genetic polymorphism, Meta-analysis
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-020-01510-4