Participation of Free-Radical Processes in Structural and Metabolic Disturbances in the Lung Tissues Caused by Exposure to Coal-Rock Dust and their Adaptogenic Correction

• Published in: Bulletin of experimental biology and medicine 2020-02, Vol.168 (4), p.439-443
• Main Authors: Zhukova, A. G., Mikhailova, N. N., Sazontova, T. G., Zhdanova, N. N., Kazitskaya, A. S., Bugaeva, M. S., Gorokhova, L. G., Arkhipenko, Yu. V.
• Format: Article
• Language: English
• Subjects: Administration, Oral; Alanine Transaminase - genetics; Alanine Transaminase - metabolism; Animal experimentation; Animals; Animals, Outbred Strains; Antioxidants; Antioxidants - pharmacology; Aspartate Aminotransferases - genetics; Aspartate Aminotransferases - metabolism; Biomedical and Life Sciences; Biomedicine; Biophysics and Biochemistry; Catalase - genetics; Catalase - metabolism; Cell Biology; Coal - adverse effects; Drug Administration Schedule; Dust; Free Radicals - antagonists & inhibitors; Free Radicals - metabolism; Gene Expression - drug effects; Granuloma - etiology; Granuloma - genetics; Granuloma - pathology; Granuloma - prevention & control; Heme Oxygenase (Decyclizing) - genetics; Heme Oxygenase (Decyclizing) - metabolism; HSP72 Heat-Shock Proteins - genetics; HSP72 Heat-Shock Proteins - metabolism; Hydroxybutyrate Dehydrogenase - genetics; Hydroxybutyrate Dehydrogenase - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Inhalation Exposure - adverse effects; Internal Medicine; Laboratory Medicine; Lung - drug effects; Lung - metabolism; Lung - pathology; Lung diseases; Male; Oxidation-Reduction; Particle Size; Pathology; Proteins; Quercetin - analogs & derivatives; Quercetin - pharmacology; Rats; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-020-04727-7

Adaptive correction of structural and metabolic disturbances in the lungs caused by longterm exposure to coal - rock dust were studied in experiments on rats. It was shown that the complex antioxidant preparation containing dihydroquercetin compensated disturbances in the redox balance in the lung tissue, prevented the formation of dust granulomas, and reduced the severity of degenerative changes in the bronchopulmonary system.