Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68

We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid ( 68 Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) ( 68 Ga-DTPMP) in intact Wistar rats. It was shown that 68 Ga-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/m...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-04, Vol.168 (6), p.777-780
Main Authors: Tishchenko, V. K., Petriev, V. M., Mikhailovskaya, A. A., Stepchenkova, E. D., Timoshenko, V. Yu, Postnov, A. A., Zavestovskaya, I. N.
Format: Article
Language:English
Subjects:
Animals
Biological Availability
Biomedical and Life Sciences
Biomedicine
Cell Biology
Etidronic Acid - blood
Etidronic Acid - pharmacokinetics
Female
Femur - diagnostic imaging
Gallium Radioisotopes - blood
Gallium Radioisotopes - pharmacokinetics
Internal Medicine
Laboratory Medicine
Metastasis
Oncology
Organ Specificity
Pathology
Phosphonates
Phosphorous Acids - blood
Phosphorous Acids - pharmacokinetics
Positron-Emission Tomography - methods
Prostate cancer
Radiopharmaceuticals - blood
Radiopharmaceuticals - pharmacokinetics
Rats
Rats, Wistar
Tissue Distribution
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Summary:We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid ( 68 Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) ( 68 Ga-DTPMP) in intact Wistar rats. It was shown that 68 Ga-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, 68 Ga-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So 68 Ga-DTPMP can be considered as a new prospective radiotracer in oncology for imaging bone tissue metastasis by positron emission tomography.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04800-1