Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres

Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modifi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-04, Vol.168 (6), p.785-788
Main Authors: Milto, I. V., Ivanova, V. V., Shevtsova, N. M., Sukhodolo, I. V.
Format: Article
Language:English
Subjects:
Animals
Animals, Outbred Strains
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chitosan - chemistry
Health aspects
Injections, Intravenous
Internal Medicine
Laboratory Medicine
Leukocyte Count
Lymphocytes
Lymphocytes - cytology
Lymphocytes - drug effects
Magnetite
Magnetite Nanoparticles - administration & dosage
Magnetite Nanoparticles - chemistry
Male
Monocytes - cytology
Monocytes - drug effects
Nanospheres - administration & dosage
Nanospheres - chemistry
Neutrophils - cytology
Neutrophils - drug effects
Particle Size
Pathology
Rats
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Summary:Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04802-z