Dietary nitrate does not alter cardiac function, calcium handling proteins, or SERCA activity in the left ventricle of healthy rats

Dietary nitrate has been shown to increase cytosolic calcium concentrations within the heart, which would necessitate greater calcium sequestration for relaxation. In the present study we demonstrate that while nitrate supplementation reduced blood pressure, calcium-handling protein content, sarco(e...

Full description

Saved in:
Bibliographic Details
Published in:Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2020-09, Vol.45 (9), p.1049-1053
Main Authors: Kirsh, Aleah J, Juracic, Emma S, Petrick, Heather L, Monaco, Cynthia M.F, Barbeau, Pierre-Andre, Tupling, A. Russell, Holloway, Graham P
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Biochemistry
Blood pressure
calcium
cardiac function
Cardiovascular system
cœur
Diet
fonction cardiaque
Heart
nitrate
Nitrates
Proteins
Rodents
régime alimentaire
SERCA
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dietary nitrate has been shown to increase cytosolic calcium concentrations within the heart, which would necessitate greater calcium sequestration for relaxation. In the present study we demonstrate that while nitrate supplementation reduced blood pressure, calcium-handling protein content, sarco(endo)plasmic reticulum Ca-ATPase 2a (SERCA) enzymatic properties, and left ventricular function were not altered. In addition, nitrite did not alter in vitro SERCA activity. Combined, these data suggest that in healthy rats, dietary nitrate does not increase left ventricle SERCA-related calcium-handling properties. Novelty Dietary nitrate decreases blood pressure but does not alter left ventricular calcium-handling protein content or SERCA activity in healthy rats.
ISSN:1715-5312
1715-5320
DOI:10.1139/apnm-2020-0078