Analysis of the Cerebrovascular Effect of a Dibenzofuran Oxime Derivative

The cerebrovascular properties of 3,4,6,7,8,9-hexahydrodibenzo[ b,d ]furan-1(2 H )-one O -(4-cinnamoyl)oxime (C 21 H 21 NO 3 , GIZ-272) were studied. The ability of GIZ-272 to improve the brain blood supply in rats subjected to global transient ischemia and to a lesser extent in animals with a hemor...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2020-09, Vol.54 (6), p.564-567
Main Authors: Mirzoyan, R. S., Gan’shina, T. S., Kurdyumov, I. N., Kurza, E. V., Maslennikov, D. V., Turilova, A. I., Zhmurenko, L. M.
Format: Article
Language:English
Subjects:
GABA
Ischemia
Lamotrigine
Levetiracetam
Medicine
Nimodipine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The cerebrovascular properties of 3,4,6,7,8,9-hexahydrodibenzo[ b,d ]furan-1(2 H )-one O -(4-cinnamoyl)oxime (C 21 H 21 NO 3 , GIZ-272) were studied. The ability of GIZ-272 to improve the brain blood supply in rats subjected to global transient ischemia and to a lesser extent in animals with a hemorrhagic stroke model was established. The compound had cerebrovascular anti-ischemic activity comparable to that of Mexidol and a duration of action longer than that of nimodipine. It is important to note that GIZ-272 did not cause a decrease in blood pressure and was superior to both Mexidol and nimodipine in this respect. An analysis of the cerebrovascular effect of GIZ-272 using bicucullin indicated that the GABA-ergic system of cerebral vessels participated in implementation of the anti-ischemic effect of the compound.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02240-9