Deciphering the Role of Innate Immune NF-kB Pathway in Pancreatic Cancer

Simple Summary: Chronic inflammation is a major mechanism that underlies the aggressive nature and treatment resistance of pancreatic cancer. In many ways, the molecular mechanisms that drive chronic inflammation in pancreatic cancer are very similar to our body's normal innate immune response...

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Bibliographic Details
Published in:Cancers 2020-09, Vol.12 (9), p.1
Main Authors: Khurana, Namrata, Dodhiawala, Paarth B, Bulle, Ashenafi, Lim, Kian-Huat
Format: Article
Language:English
Subjects:
Pancreatic cancer
Physiological aspects
Online Access:Get full text
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Summary:Simple Summary: Chronic inflammation is a major mechanism that underlies the aggressive nature and treatment resistance of pancreatic cancer. In many ways, the molecular mechanisms that drive chronic inflammation in pancreatic cancer are very similar to our body's normal innate immune response to injury or invading microorganisms. Therefore, during cancer development, pancreatic cancer cells hijack the innate immune pathway to foster a chronically inflamed tumor environment that helps shield them from immune attack and therapeutics. While blocking the innate immune pathway is theoretically reasonable, untoward side effects must also be addressed. In this review, we comprehensively summarize the literature that describe the role of innate immune signaling in pancreatic cancer, emphasizing the specific role of this pathway in different cell types. We review the interaction of the innate immune pathway and cancer-driving signaling in pancreatic cancer and provide an updated overview of novel therapeutic opportunities against this mechanism.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12092675