Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona ajfinis postica: in silico, in vitro, and in vivo Studies

Bees are of great importance for plant diversity for being an important pollinating agents. Stingless bees such as Scaptotrigona ajfinis postica, is cultivated largely due to the products offered by it. Pollen is one of these products, which has been highlighted for exhibit various therapeutic prope...

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Bibliographic Details
Published in:Antioxidants 2020-02, Vol.9 (2), p.1
Main Authors: Lopes, Alberto Jorge Oliveira, Vasconcelos, Cleydlenne Costa, Garcia, Joao Batista Santos, Pinheiro, Myssa Sued Doria, Pereira, Francisco Assis Nascimento, Camelo, Darleno de Sousa, de Morais, Sebastiao Vieira, Freitas, Jose Roberto Brito, da Rocha, Claudia Quintino, Ribeiro, Maria Nike de Sousa, Cartagenes, Maria do Socorro de Sousa
Format: Article
Language:English
Subjects:
Bees
Health aspects
Physiological aspects
Pollen
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Summary:Bees are of great importance for plant diversity for being an important pollinating agents. Stingless bees such as Scaptotrigona ajfinis postica, is cultivated largely due to the products offered by it. Pollen is one of these products, which has been highlighted for exhibit various therapeutic properties. Considering the bioactivity of this natural product, this study investigated the antioxidant, anti-inflammatory, antinociceptive activities, and elucidated the chemical composition of pollen collected extract by Scaptotrigona affinis postica. Using in vitro assays, the antioxidant potential and inhibitory activity against the COX enzyme from pollen extract was evaluated. Additionally, tests were performed to measure the anti-inflammatory and antinociceptive activities in animal models. In our results, we found that pollen extract showed antioxidant effects and inhibitory activity against the COX enzyme. The in vivo assays showed that the extract acts on the nervous system in local and systemic levels and that the anti-inflammatory activity is due the prostanoids reducing. Chemical analyses recognize 10 molecules in the extract belonging to the polyphenol and flavonoids classes and the computational study suggests that is responsible for the observed results. Thus, it is reported for the first time the biological potential of S. off. postica pollen extract and we conclude that this bee product can be considered as one source of potential new drugs.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9020103