tRNA-Derived Small RNAs: Novel Epigenetic Regulators

Cells must synthesize new proteins to maintain its life and tRNA (transfer RNA) is an essential component of the translation process. tRNA-derived small RNA (tsRNA) is a relatively uncharacterized small RNA, derived from enzymatic cleavage of the tRNAs. Accumulating evidences suggest that tsRNA is a...

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Bibliographic Details
Published in:Cancers 2020, Vol.12 (10), p.1
Main Authors: Park, Joonhyeong, Ahn, Se Hee, Shin, Myung Geun, Kim, Hak Kyun, Chang, Suhwan
Format: Report
Language:English
Subjects:
Epigenetic inheritance
Health aspects
Transfer RNA
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Summary:Cells must synthesize new proteins to maintain its life and tRNA (transfer RNA) is an essential component of the translation process. tRNA-derived small RNA (tsRNA) is a relatively uncharacterized small RNA, derived from enzymatic cleavage of the tRNAs. Accumulating evidences suggest that tsRNA is an abundant, highly modified, dynamically regulated small-RNA and interacts with other types of RNAs or proteins. Moreover, it is abnormally expressed in multiple human diseases including systemic lupus, neurological disorder, metabolic disorder and cancer, implying its diverse function in the initiation or progression of such diseases. In this review, we summarize the classification of tsRNA and its role focused on the epigenetic regulation. Further, we discuss the limitation of current knowledge about the tsRNA and its potential applications.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12102773