Correlation of C-arm CT acquired parenchymal blood volume SPECT/CT for radioembolization work-up

Objective SPECT/CT with .sup.99m Tc-macroaggregated albumin (MAA) is generally used for diagnostic work-up prior to transarterial radioembolization (TARE) to exclude shunts and to provide additional information for treatment stratification and dose calculation. C-arm CT is used for determination of...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2020-12, Vol.15 (12), p.e0244235
Main Authors: Weissinger, Matthias, Vogel, Jonas, Kupferschlager, Jürgen, Dittmann, Helmut, Castaneda Vega, Salvador Guillermo, Grosse, Ulrich, Artzner, Christoph, Nikolaou, Konstantin, la Fougere, Christian, Grozinger, Gerd
Format: Article
Language:English
Subjects:
Blood
Colorectal cancer
CT imaging
Diagnosis
Hepatoma
Isotopes
Medical examination
Metastasis
Methods
Technetium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective SPECT/CT with .sup.99m Tc-macroaggregated albumin (MAA) is generally used for diagnostic work-up prior to transarterial radioembolization (TARE) to exclude shunts and to provide additional information for treatment stratification and dose calculation. C-arm CT is used for determination of lobular vascular supply and assessment of parenchymal blood volume (PBV). Aim of this study was to correlate MAA-uptake and PBV-maps in hepatocellular carcinoma (HCC) and hepatic metastases of the colorectal carcinoma (CRC). Materials and methods 34 patients underwent a PBV C-arm CT immediately followed by .sup.99m Tc-MAA injection and a SPECT/CT acquisition after 1 h uptake. MAA-uptake and PBV-maps were visually assessed and semi-quantitatively analyzed (MAA-tumor/liver-parenchyma = MAA-TBR or PBV in ml/100ml). In case of a poor match, tumors were additionally correlated with post-TARE .sup.90 Y-Bremsstrahlung-SPECT/CT as a reference. Results 102 HCC or CRC metastases were analyzed. HCC presented with significantly higher MAA-TBR (7.6 vs. 3.9, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0244235