Comparison and Analyses of Intraoperative Consultation and Paraffin Section Responses of Ovarian Lesions/Over Lezyonlarinda Intraoperatif Konsultasyon Yanitlarinin ve Parafin Tanilarinin Karsilastirilmasi ve Degerlendirilmesi

Objective: We aimed to analyze the sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and the accuracy of frozen section (FS) method and compare the concordance of FS responses and paraffin section (PS) (final histopathological diagnoses) results of the o...

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Published in:Journal of academic research in medicine 2020-12, Vol.10 (3), p.237
Main Authors: Kimiloglu, Elife, Yanik, Irem, Gündogar, Ozgecan, Bektas, Sibel, Salman, Süleyman
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Care and treatment
Diagnosis
Diagnosis, Surgical
Frozen tissue sections
Methods
Ovarian tumors
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Yanik, Irem
Gündogar, Ozgecan
Bektas, Sibel
Salman, Süleyman
description Objective: We aimed to analyze the sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and the accuracy of frozen section (FS) method and compare the concordance of FS responses and paraffin section (PS) (final histopathological diagnoses) results of the ovarian mass operations in our hospital. Methods: We retrospectively reviewed the cases of ovarian lesions operated between March 2008 and June 2018 in which FS was requested. In total 205 cases were found and the results were compared. The FS responses and PS results were classified as benign, borderline and malignant. Seventeen cases weren't responded in FS (and left to be diagnosed in PS) and they were left out of the study. Results: According to the analyses; the sensitivity of benign, borderline and malignant tumors were 100%, 83%, 95%, and the specificity were 98%, 99%, 98%, respectively. The PPV of borderline and malignant tumors were 91%, 92% and the NPV were 98%, 99% respectively. Furthermore; both of their accuracy was 97%. The concordance between the methods was assessed with Kappa test and found as 94% (p
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Methods: We retrospectively reviewed the cases of ovarian lesions operated between March 2008 and June 2018 in which FS was requested. In total 205 cases were found and the results were compared. The FS responses and PS results were classified as benign, borderline and malignant. Seventeen cases weren't responded in FS (and left to be diagnosed in PS) and they were left out of the study. Results: According to the analyses; the sensitivity of benign, borderline and malignant tumors were 100%, 83%, 95%, and the specificity were 98%, 99%, 98%, respectively. The PPV of borderline and malignant tumors were 91%, 92% and the NPV were 98%, 99% respectively. Furthermore; both of their accuracy was 97%. The concordance between the methods was assessed with Kappa test and found as 94% (p&lt;0.001). Conclusion: In our study we showed that even if all of the FS responses didn't match with its PS, FS has a very high rate of consistency. FS is a way to help the surgeon during the operation. However, it must not be forgotten that this method has its own pitfalls and limitations. Keywords: Ovary, frozen section, paraffin section, diagnosis accuracy Amaç: Bu çalismada hastanemiz bünyesinde yapilan uterin adneksiyal kitle operasyonlarinin intraoperatif konsültasyon yanitlari ve tanilarini karsilastirmayi ve uyum ve uyumsuzluklarini degerlendirip, intraoperatif konsültasyonun benign, borderline ve malign ovaryan lezyonlardaki duyarliligini, özgüllügünü, pozitif-negatif prediktif degerlerini ve dogruluk oranlarini degerlendirmeyi amaçladik. Yöntemler: Hastanemizde Mart 2008 ve Haziran 2018 tarihleri arasinda opere olan ve intraoperatif patoloji konsültasyonu yapilan uterin adneksiyal kitle olgulari retrospektif olarak tarandi. Toplamda 205 olgu elde edildi ve sonuçlar karsilastirildi. Frozen yanitlari ve parafin tanilari; benign, borderline ve malign olarak gruplandi. Frozen esnasinda yanit verilmeyen, parafine birakilan 17 olgu çalismanin disinda birakildi. Bulgular: Istatistiksel analiz sonuçlarina göre benign, borderline ve malign tümörlerin intraoperatif konsültasyon sensitivitesi sirasiyla, %100, %83 ve %95 olarak degerlendirilirken, spesifitesi de ayni sirayla %98, %99, %98 olarak degerlendirildi. Borderline ve malign tümörlerin pozitif prediktif degerleri ise %91 ve %92, negatif prediktif degerleri %98 ve %99 ve dogruluk orani ise her ikisinin de %97 olarak degerlendirildi. Yöntemler arasindaki uyum Kappa testi ile degerlendirildi ve %94[+ or -]0,03 (p&lt;0,001) olarak bulundu. Sonuç: Intraoperatif konsültasyon yanitlarinin nihai parafin tanilari tamamen uyumlu olmasa da çok yüksek oranda uyum gösterdigi gözlenmis olup günlük pratigimizdeki önemli yerini korumaktadir. Ancak bu bulgular esliginde intraoperatif konsültasyon yanitlarinin da sinirliliklarinin oldugu operasyona giren cerrahlar tarafindan unutulmamali ve operasyon seklini belirlerken akilda tutulmalidir. Anahtar kelimeler: Over, frozen yaniti, parafin tani, tani uyumu</description><identifier>ISSN: 2146-6505</identifier><identifier>DOI: 10.4274/jarem.galenos.2020.3185</identifier><language>eng</language><publisher>AVES</publisher><subject>Care and treatment ; Diagnosis ; Diagnosis, Surgical ; Frozen tissue sections ; Methods ; Ovarian tumors</subject><ispartof>Journal of academic research in medicine, 2020-12, Vol.10 (3), p.237</ispartof><rights>COPYRIGHT 2020 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kimiloglu, Elife</creatorcontrib><creatorcontrib>Yanik, Irem</creatorcontrib><creatorcontrib>Gündogar, Ozgecan</creatorcontrib><creatorcontrib>Bektas, Sibel</creatorcontrib><creatorcontrib>Salman, Süleyman</creatorcontrib><title>Comparison and Analyses of Intraoperative Consultation and Paraffin Section Responses of Ovarian Lesions/Over Lezyonlarinda Intraoperatif Konsultasyon Yanitlarinin ve Parafin Tanilarinin Karsilastirilmasi ve Degerlendirilmesi</title><title>Journal of academic research in medicine</title><description>Objective: We aimed to analyze the sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and the accuracy of frozen section (FS) method and compare the concordance of FS responses and paraffin section (PS) (final histopathological diagnoses) results of the ovarian mass operations in our hospital. Methods: We retrospectively reviewed the cases of ovarian lesions operated between March 2008 and June 2018 in which FS was requested. In total 205 cases were found and the results were compared. The FS responses and PS results were classified as benign, borderline and malignant. Seventeen cases weren't responded in FS (and left to be diagnosed in PS) and they were left out of the study. Results: According to the analyses; the sensitivity of benign, borderline and malignant tumors were 100%, 83%, 95%, and the specificity were 98%, 99%, 98%, respectively. The PPV of borderline and malignant tumors were 91%, 92% and the NPV were 98%, 99% respectively. Furthermore; both of their accuracy was 97%. The concordance between the methods was assessed with Kappa test and found as 94% (p&lt;0.001). Conclusion: In our study we showed that even if all of the FS responses didn't match with its PS, FS has a very high rate of consistency. FS is a way to help the surgeon during the operation. However, it must not be forgotten that this method has its own pitfalls and limitations. Keywords: Ovary, frozen section, paraffin section, diagnosis accuracy Amaç: Bu çalismada hastanemiz bünyesinde yapilan uterin adneksiyal kitle operasyonlarinin intraoperatif konsültasyon yanitlari ve tanilarini karsilastirmayi ve uyum ve uyumsuzluklarini degerlendirip, intraoperatif konsültasyonun benign, borderline ve malign ovaryan lezyonlardaki duyarliligini, özgüllügünü, pozitif-negatif prediktif degerlerini ve dogruluk oranlarini degerlendirmeyi amaçladik. Yöntemler: Hastanemizde Mart 2008 ve Haziran 2018 tarihleri arasinda opere olan ve intraoperatif patoloji konsültasyonu yapilan uterin adneksiyal kitle olgulari retrospektif olarak tarandi. Toplamda 205 olgu elde edildi ve sonuçlar karsilastirildi. Frozen yanitlari ve parafin tanilari; benign, borderline ve malign olarak gruplandi. Frozen esnasinda yanit verilmeyen, parafine birakilan 17 olgu çalismanin disinda birakildi. Bulgular: Istatistiksel analiz sonuçlarina göre benign, borderline ve malign tümörlerin intraoperatif konsültasyon sensitivitesi sirasiyla, %100, %83 ve %95 olarak degerlendirilirken, spesifitesi de ayni sirayla %98, %99, %98 olarak degerlendirildi. Borderline ve malign tümörlerin pozitif prediktif degerleri ise %91 ve %92, negatif prediktif degerleri %98 ve %99 ve dogruluk orani ise her ikisinin de %97 olarak degerlendirildi. Yöntemler arasindaki uyum Kappa testi ile degerlendirildi ve %94[+ or -]0,03 (p&lt;0,001) olarak bulundu. Sonuç: Intraoperatif konsültasyon yanitlarinin nihai parafin tanilari tamamen uyumlu olmasa da çok yüksek oranda uyum gösterdigi gözlenmis olup günlük pratigimizdeki önemli yerini korumaktadir. Ancak bu bulgular esliginde intraoperatif konsültasyon yanitlarinin da sinirliliklarinin oldugu operasyona giren cerrahlar tarafindan unutulmamali ve operasyon seklini belirlerken akilda tutulmalidir. Anahtar kelimeler: Over, frozen yaniti, parafin tani, tani uyumu</description><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Diagnosis, Surgical</subject><subject>Frozen tissue sections</subject><subject>Methods</subject><subject>Ovarian tumors</subject><issn>2146-6505</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkc9KAzEQxvegoKjPYMBz12w22U2Ppf7FQkV78VRms5MS2U1Kshb0bX0Tp7WCguSQzDe_-T6SZNl5wXMpann5ChH7fAUd-pBywQXPy0Krg-xYFLIaVYqro-wspVfOeVFrMZbiOPuchn4N0aXgGfiWTTx07wkTC5bd-yFCWGOEwW2QTYNPb91AxZ59hAjWOs-e0ezEJ0xrgr6n5xuyBc9mmKiXLucbjFR8vAffUce38CfAsoe9fyKCvYB3w44jfwrfZdFxQfqP_AAxUZEGF13XQ3Jb8ApXGOkJ2p1I2afZoYUu4dl-P8kWN9eL6d1oNr-9n05mo1VVy1Fbg66LplHa6rpRwopq3ChTWlFqLnSppCkMtpyrWiMIVLIxjbFSGM7NWEN5kl18224_YOm8DXQ307tklpNK6rIU9AtE5f9QtFrsnQkerSP918AXzuabWw</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Kimiloglu, Elife</creator><creator>Yanik, Irem</creator><creator>Gündogar, Ozgecan</creator><creator>Bektas, Sibel</creator><creator>Salman, Süleyman</creator><general>AVES</general><scope/></search><sort><creationdate>20201201</creationdate><title>Comparison and Analyses of Intraoperative Consultation and Paraffin Section Responses of Ovarian Lesions/Over Lezyonlarinda Intraoperatif Konsultasyon Yanitlarinin ve Parafin Tanilarinin Karsilastirilmasi ve Degerlendirilmesi</title><author>Kimiloglu, Elife ; Yanik, Irem ; Gündogar, Ozgecan ; Bektas, Sibel ; Salman, Süleyman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g674-d7a871bb58f87b52f269b5c3f238028354c1ced00578ea2e54bcbcf42c00c98a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Diagnosis, Surgical</topic><topic>Frozen tissue sections</topic><topic>Methods</topic><topic>Ovarian tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimiloglu, Elife</creatorcontrib><creatorcontrib>Yanik, Irem</creatorcontrib><creatorcontrib>Gündogar, Ozgecan</creatorcontrib><creatorcontrib>Bektas, Sibel</creatorcontrib><creatorcontrib>Salman, Süleyman</creatorcontrib><jtitle>Journal of academic research in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimiloglu, Elife</au><au>Yanik, Irem</au><au>Gündogar, Ozgecan</au><au>Bektas, Sibel</au><au>Salman, Süleyman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison and Analyses of Intraoperative Consultation and Paraffin Section Responses of Ovarian Lesions/Over Lezyonlarinda Intraoperatif Konsultasyon Yanitlarinin ve Parafin Tanilarinin Karsilastirilmasi ve Degerlendirilmesi</atitle><jtitle>Journal of academic research in medicine</jtitle><date>2020-12-01</date><risdate>2020</risdate><volume>10</volume><issue>3</issue><spage>237</spage><pages>237-</pages><issn>2146-6505</issn><abstract>Objective: We aimed to analyze the sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and the accuracy of frozen section (FS) method and compare the concordance of FS responses and paraffin section (PS) (final histopathological diagnoses) results of the ovarian mass operations in our hospital. Methods: We retrospectively reviewed the cases of ovarian lesions operated between March 2008 and June 2018 in which FS was requested. In total 205 cases were found and the results were compared. The FS responses and PS results were classified as benign, borderline and malignant. Seventeen cases weren't responded in FS (and left to be diagnosed in PS) and they were left out of the study. Results: According to the analyses; the sensitivity of benign, borderline and malignant tumors were 100%, 83%, 95%, and the specificity were 98%, 99%, 98%, respectively. The PPV of borderline and malignant tumors were 91%, 92% and the NPV were 98%, 99% respectively. Furthermore; both of their accuracy was 97%. The concordance between the methods was assessed with Kappa test and found as 94% (p&lt;0.001). Conclusion: In our study we showed that even if all of the FS responses didn't match with its PS, FS has a very high rate of consistency. FS is a way to help the surgeon during the operation. However, it must not be forgotten that this method has its own pitfalls and limitations. Keywords: Ovary, frozen section, paraffin section, diagnosis accuracy Amaç: Bu çalismada hastanemiz bünyesinde yapilan uterin adneksiyal kitle operasyonlarinin intraoperatif konsültasyon yanitlari ve tanilarini karsilastirmayi ve uyum ve uyumsuzluklarini degerlendirip, intraoperatif konsültasyonun benign, borderline ve malign ovaryan lezyonlardaki duyarliligini, özgüllügünü, pozitif-negatif prediktif degerlerini ve dogruluk oranlarini degerlendirmeyi amaçladik. Yöntemler: Hastanemizde Mart 2008 ve Haziran 2018 tarihleri arasinda opere olan ve intraoperatif patoloji konsültasyonu yapilan uterin adneksiyal kitle olgulari retrospektif olarak tarandi. Toplamda 205 olgu elde edildi ve sonuçlar karsilastirildi. Frozen yanitlari ve parafin tanilari; benign, borderline ve malign olarak gruplandi. Frozen esnasinda yanit verilmeyen, parafine birakilan 17 olgu çalismanin disinda birakildi. Bulgular: Istatistiksel analiz sonuçlarina göre benign, borderline ve malign tümörlerin intraoperatif konsültasyon sensitivitesi sirasiyla, %100, %83 ve %95 olarak degerlendirilirken, spesifitesi de ayni sirayla %98, %99, %98 olarak degerlendirildi. Borderline ve malign tümörlerin pozitif prediktif degerleri ise %91 ve %92, negatif prediktif degerleri %98 ve %99 ve dogruluk orani ise her ikisinin de %97 olarak degerlendirildi. Yöntemler arasindaki uyum Kappa testi ile degerlendirildi ve %94[+ or -]0,03 (p&lt;0,001) olarak bulundu. Sonuç: Intraoperatif konsültasyon yanitlarinin nihai parafin tanilari tamamen uyumlu olmasa da çok yüksek oranda uyum gösterdigi gözlenmis olup günlük pratigimizdeki önemli yerini korumaktadir. Ancak bu bulgular esliginde intraoperatif konsültasyon yanitlarinin da sinirliliklarinin oldugu operasyona giren cerrahlar tarafindan unutulmamali ve operasyon seklini belirlerken akilda tutulmalidir. Anahtar kelimeler: Over, frozen yaniti, parafin tani, tani uyumu</abstract><pub>AVES</pub><doi>10.4274/jarem.galenos.2020.3185</doi></addata></record>
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subjects Care and treatment
Diagnosis
Diagnosis, Surgical
Frozen tissue sections
Methods
Ovarian tumors
title Comparison and Analyses of Intraoperative Consultation and Paraffin Section Responses of Ovarian Lesions/Over Lezyonlarinda Intraoperatif Konsultasyon Yanitlarinin ve Parafin Tanilarinin Karsilastirilmasi ve Degerlendirilmesi
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