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Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis
Introduction: Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective: The biological and clinical relevance of neutr...
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Published in: | Journal of inflammation research 2020-12, Vol.13, p.1113 |
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creator | Chen, Hong-Peng Wang, Xiao-Yan Pan, Xiao-Yan Hu, Wang-Wang Cai, Shu-Ting Joshi, Kiran Deng, Lie-Hua Ma, Daqing |
description | Introduction: Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective: The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. Methods: The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. Results: On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-[alpha] levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality. Conclusion: Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study. Keywords: sepsis, septic shock, cell-derived microparticles, biomarker, prognosis |
doi_str_mv | 10.2147/JIR.S267256 |
format | article |
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Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective: The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. Methods: The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. Results: On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-[alpha] levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality. Conclusion: Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study. Keywords: sepsis, septic shock, cell-derived microparticles, biomarker, prognosis</description><identifier>ISSN: 1178-7031</identifier><identifier>EISSN: 1178-7031</identifier><identifier>DOI: 10.2147/JIR.S267256</identifier><language>eng</language><publisher>Dove Medical Press Limited</publisher><subject>Analysis ; China ; Ethylenediaminetetraacetic acid ; Health aspects ; Infection ; Information management ; Medical colleges ; Mortality ; Political aspects ; Prognosis ; Septic shock ; United Kingdom</subject><ispartof>Journal of inflammation research, 2020-12, Vol.13, p.1113</ispartof><rights>COPYRIGHT 2020 Dove Medical Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Chen, Hong-Peng</creatorcontrib><creatorcontrib>Wang, Xiao-Yan</creatorcontrib><creatorcontrib>Pan, Xiao-Yan</creatorcontrib><creatorcontrib>Hu, Wang-Wang</creatorcontrib><creatorcontrib>Cai, Shu-Ting</creatorcontrib><creatorcontrib>Joshi, Kiran</creatorcontrib><creatorcontrib>Deng, Lie-Hua</creatorcontrib><creatorcontrib>Ma, Daqing</creatorcontrib><title>Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis</title><title>Journal of inflammation research</title><description>Introduction: Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective: The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. Methods: The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. Results: On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-[alpha] levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality. Conclusion: Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study. Keywords: sepsis, septic shock, cell-derived microparticles, biomarker, prognosis</description><subject>Analysis</subject><subject>China</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Information management</subject><subject>Medical colleges</subject><subject>Mortality</subject><subject>Political aspects</subject><subject>Prognosis</subject><subject>Septic shock</subject><subject>United Kingdom</subject><issn>1178-7031</issn><issn>1178-7031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjD1PwzAQhi0EEhV04g9YYk6xE8eOx6p8FRWoaPfKcc7poTSuYhf-PkZl6MDdcKfn_SDkhrNJzoW6e5l_TFa5VHkpz8iIc1VlihX8_OS_JOMQPtnvKCZyMSJ2hoM9dCZi39I3OMTB77fYZfcw4Bc09BVtImaIaDsIdBqCt2hiUr4xbmncAl0Ovu19wEC9o8vUBH0MR3kF-8SvyYUzXYDx370i68eH9ew5W7w_zWfTRdZKJbLCOK0dM2XZcCiZNlDoSjjlapkrzZywjSsUsJKBqRWvAZRo6spaIXSe1OKK3B5rW9PBBnvn42DsDoPdTKXQsiqUFMk1-ceVtoEdWt-Dw8RPAj-oqGi6</recordid><startdate>20201231</startdate><enddate>20201231</enddate><creator>Chen, Hong-Peng</creator><creator>Wang, Xiao-Yan</creator><creator>Pan, Xiao-Yan</creator><creator>Hu, Wang-Wang</creator><creator>Cai, Shu-Ting</creator><creator>Joshi, Kiran</creator><creator>Deng, Lie-Hua</creator><creator>Ma, Daqing</creator><general>Dove Medical Press Limited</general><scope/></search><sort><creationdate>20201231</creationdate><title>Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis</title><author>Chen, Hong-Peng ; Wang, Xiao-Yan ; Pan, Xiao-Yan ; Hu, Wang-Wang ; Cai, Shu-Ting ; Joshi, Kiran ; Deng, Lie-Hua ; Ma, Daqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g674-3af99f0a55d1e509ae3984f7fb62790f4cdf37e050eab71bee74db8cc4492f4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>China</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Information management</topic><topic>Medical colleges</topic><topic>Mortality</topic><topic>Political aspects</topic><topic>Prognosis</topic><topic>Septic shock</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hong-Peng</creatorcontrib><creatorcontrib>Wang, Xiao-Yan</creatorcontrib><creatorcontrib>Pan, Xiao-Yan</creatorcontrib><creatorcontrib>Hu, Wang-Wang</creatorcontrib><creatorcontrib>Cai, Shu-Ting</creatorcontrib><creatorcontrib>Joshi, Kiran</creatorcontrib><creatorcontrib>Deng, Lie-Hua</creatorcontrib><creatorcontrib>Ma, Daqing</creatorcontrib><jtitle>Journal of inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hong-Peng</au><au>Wang, Xiao-Yan</au><au>Pan, Xiao-Yan</au><au>Hu, Wang-Wang</au><au>Cai, Shu-Ting</au><au>Joshi, Kiran</au><au>Deng, Lie-Hua</au><au>Ma, Daqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis</atitle><jtitle>Journal of inflammation research</jtitle><date>2020-12-31</date><risdate>2020</risdate><volume>13</volume><spage>1113</spage><pages>1113-</pages><issn>1178-7031</issn><eissn>1178-7031</eissn><abstract>Introduction: Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective: The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. Methods: The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. Results: On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-[alpha] levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality. Conclusion: Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study. Keywords: sepsis, septic shock, cell-derived microparticles, biomarker, prognosis</abstract><pub>Dove Medical Press Limited</pub><doi>10.2147/JIR.S267256</doi></addata></record> |
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source | Taylor & Francis; Publicly Available Content (ProQuest); PubMed Central |
subjects | Analysis China Ethylenediaminetetraacetic acid Health aspects Infection Information management Medical colleges Mortality Political aspects Prognosis Septic shock United Kingdom |
title | Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis |
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