Slipping Through the Pores: Hypoalbuminemia and Albumin Loss During Hemodialysis

Hypoalbuminemia results when compensatory mechanisms are unable to keep pace with derangements in catabolism/loss and/or decreased synthesis of albumin. Across many disease states, including chronic kidney disease (CKD), hypoalbuminemia is a well established, independent risk factor for adverse outc...

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Bibliographic Details
Published in:International journal of nephrology and renovascular disease 2021-01, Vol.14, p.11
Main Authors: Kalantar-Zadeh, Kamyar, Ficociello, Linda H, Bazzanella, Jennifer, Mullon, Claudy, Anger, Michael S
Format: Article
Language:English
Subjects:
Albumin
Chronic kidney failure
Health aspects
Hemodialysis
Risk factors
Type 2 diabetes
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Summary:Hypoalbuminemia results when compensatory mechanisms are unable to keep pace with derangements in catabolism/loss and/or decreased synthesis of albumin. Across many disease states, including chronic kidney disease (CKD), hypoalbuminemia is a well established, independent risk factor for adverse outcomes, including mortality. In the setting of CKD, reduced serum albumin concentrations are often a manifestation of protein-energy wasting, a state of metabolic and nutritional alterations resulting in reduced protein and energy stores. The progression of CKD to kidney failure and the initiation of maintenance hemodialysis (HD) further predisposes an already at-risk population toward hypoalbuminemia such that approximately 60% of HD patients have albumin concentrations
ISSN:1178-7058
1178-7058
DOI:10.2l47/IJNRD.S29l348