A Novel Marker Affecting Survival in Acute Non-variceal Upper Gastrointestinal Bleeding: Cardiac Troponin I/Akut Varis Disi Ust Gastrointestinal Kanamada Sagkalimi Etkileyen Yeni Bir Belirtec: Kardiyak Troponin I

• Published in: Istanbul medical journal 2021-02, Vol.22 (1), p.38
• Main Authors: Dertli, Ramazan, Biyik, Murat, Yolacan, Ramazan, Keskin, Muharrem, Karakarcayildiz, Ahmet, Kayar, Yusuf, Ataseven, Huseyin, Polat, Hakki, Demir, Ali, Asil, Mehmet
• Format: Article
• Language: eng ; tur
• Subjects: Analysis; Cardiac patients; Cardiology; Chronic kidney failure; Coronary heart disease; Gastrointestinal bleeding; Health aspects; Medical research; Medicine, Experimental; Mortality
• ISSN: 2619-9793; 1304-8503
• DOI: 10.4274/imj.galenos.2020.45403

Introduction: Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is an important public health problem with high rates of morbidity and mortality. ANVUGIB results in hypovolemia, hypotension, and shock, increasing cardiac oxygen use and may cause elevated serum levels of cardiac troponin (cTn). In this study, we aimed to evaluate whether elevated cTnI has clinical significance in patients with ANVUGIB. Methods: A total of 62 patients diagnosed with ANVUGIB whose serum cTnI levels were studied at the time of admission and follow-up in our clinic from January 2015 to January 2016 were included in the study. Patients with acute cardiac diseases that may cause elevated cTn were excluded from the study. Results: Forty-three of the patients were male (69.4%), and the mean age of all patients was 71.52[+ or -]13.30 years. The mean cTnI level was 0.042[+ or -]0.097 in all patients, with cTnI levels higher than the reference value in nine (14.5%) patients. In logistic regression analysis, the factors found to contribute to cTnI were tachycardia, chronic kidney disease, and coronary artery disease. In receiver operating characteristic analysis, cutoff values of 0.025 and 6.5 were found for cTnI and the Rockall score, respectively. In addition, cTnI and the Rockall score were shown to affect survival [log-rank (Mantel-Cox) test: p=0.011; log-rank (Mantel-Cox) test: p=0.014; respectively]. Conclusion: We believe that serum cTnI levels studied during the first admission will be found useful as a biomarker in addition to the other existing risk determination systems, in order to identify patients at risk, even if findings of acute coronary syndrome are not observed in patients presenting with ANVUGIB. Keywords: cTnI, upper gastrointestinal bleeding, rockall score Amac: Akut varis disi ust gastrointestinal sistem kanamasi (AVDUGSK) yuksek mortalite ve morbiditeye sahip onemli bir saglik sorunudur. AVDUGSK'leri hipovolemi, hipotansiyon ve sok tablosu olusturarak kardiyak oksijen kullanimini artirir ve serum kardiyak troponin (kTn) duzeyinin yukselmesine neden olabilir. Biz bu calismada AVDUGSK'si olan hastalarda kTnI yuksekliginin klinik bir oneme sahip olup olmadigini degerlendirmeyi planladik. Yontemler: Klinigimize Ocak 2015-Ocak 2016 tarihleri arasinda basvuran, AVDUGSK tanisi konan, basvuru aninda serum kTnI bakilmis olan 62 hasta calismaya dahil edildi. kTn yuksekligine sebep olabilecek akut kardiyak hadisesi olan tum hastalar calisma disi birakildi. Bulgu