High virological failure rates in HIV-1 perinatally infected children in South Africa : a retrospective cohort study

Background. Large cohorts of HIV-1 perinatally infected children with long-term follow-up in developing countries are limited. Objectives. To explore rates and predictors of virological failure in a paediatric cohort. Methods. A 10-year retrospective study was conducted from January 2004 to December...

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Bibliographic Details
Published in:South African medical journal 2021-03, Vol.111 (3), p.255-259
Main Authors: Makatini, Z.N, Blackard, J.T, Mda, S, Miles, P, Towobola, O
Format: Article
Language:English
Subjects:
Drug resistance
Drug therapy
Forecasts and trends
Highly active antiretroviral therapy
HIV infection in children
Measurement
Pediatric research
Viremia
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Summary:Background. Large cohorts of HIV-1 perinatally infected children with long-term follow-up in developing countries are limited. Objectives. To explore rates and predictors of virological failure in a paediatric cohort. Methods. A 10-year retrospective study was conducted from January 2004 to December 2013 to determine the incidence of and factors associated with virological failure among 1 659 HIV perinatally infected children in a public sector setting in South Africa (SA). Children aged
ISSN:0256-9574
2078-5135
DOI:10.7196/SAMJ.2021.v111i3.15221