Adenosine [A.sub.2A] Receptor Agonist Polydeoxyribonucleotide Alleviates Interstitial Cystitis-Induced Voiding Dysfunction by Suppressing Inflammation and Apoptosis in Rats

Background: Interstitial cystitis (IC) is a chronic disorder that indicates bladder-related pain or discomfort. Patients with IC often experience urination problems, such as urinary frequency and urgency, along with pain or discomfort in the bladder area. Therefore, new treatments based on IC etiolo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of inflammation research 2021-02, Vol.14, p.367
Main Authors: Ko, Il-Gyu, Jin, Jun-Jang, Hwang, Lakkyong, Kim, Sang-Hoon, Kim, Chang-Ju, Won, Kyu Yeoun, Na, Yong Gil, Kim, Khae Hawn, Kim, Su Jin
Format: Article
Language:English
Subjects:
Adenosine
Apoptosis
Biological products industry
Computer industry
Cyclophosphamide
Inflammation
Interstitial cystitis
Physiological aspects
Scientific equipment and supplies industry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Interstitial cystitis (IC) is a chronic disorder that indicates bladder-related pain or discomfort. Patients with IC often experience urination problems, such as urinary frequency and urgency, along with pain or discomfort in the bladder area. Therefore, new treatments based on IC etiology are needed. Polydeoxyribonucleotide (PDRN) is a biologic agonist of the adenosine [A.sub.2A] receptor, and PDRN has anti-inflammatory effect and inhibits apoptosis. In the current study, the effect of PDRN on cyclophosphamide-induced IC animal model was investigated using rats. Methodology: To induce the IC animal model, 75 mg/kg of cyclophosphamide was injected intraperitoneally once every 3 days for 10 days. The rats in the PDRN-treated groups were intraperitoneally injected with 0.5 mL physiological saline containing 8 mg/kg PDRN, once a day for 10 days after IC induction. Results: Induction of IC by cyclophosphamide injection caused voiding dysfunction, bladder edema, and histological damage. Cyclophosphamide injection increased secretion of pro-inflammatory cytokines and enhanced apoptosis. In contrast, PDRN treatment alleviated voiding dysfunction, bladder edema, and histological damage. Secretion of proinflammatory cytokines and expressions of apoptotic factors were suppressed by PDRN treatment. These changes indicate that treatment with PDRN improves voiding function by ultimately promoting the repair of damaged bladder tissue. Conclusion: The conclusion of this experiment suggests the possibility that PDRN could be used as an effective therapeutic agent for IC. Keywords: interstitial cystitis, adenosine [A.sub.2A] receptor, polydeoxyribonucleotide, voiding function, inflammation, apoptosis
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S287346