LncRNA SLCI6AI-ASI Suppresses Cell Proliferation in Cervical Squamous Cell Carcinoma Through the miR-194/SOCS2 Axis

Background: SLC16A1-AS1 has been characterized as an oncogenic long non-coding (lncRNA) in breast cancer and bladder cancer, while its role in cervical squamous cell carcinoma (CSCC) is unknown. Methods: CSCC and non-tumor tissue samples were collected from 60 female patients, and qPCR was performed...

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Bibliographic Details
Published in:Cancer management and research 2021-02, Vol.13, p.1299
Main Authors: Zhang, Huizhen, Jin, Shuangling, Ji, Aifang, Ma, Ying, Zhang, Chunyan, Wang, Ailan, Wang, Rui
Format: Article
Language:English
Subjects:
Cervical cancer
Health aspects
Luciferase
Squamous cell carcinoma
Women
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Summary:Background: SLC16A1-AS1 has been characterized as an oncogenic long non-coding (lncRNA) in breast cancer and bladder cancer, while its role in cervical squamous cell carcinoma (CSCC) is unknown. Methods: CSCC and non-tumor tissue samples were collected from 60 female patients, and qPCR was performed to detect the expression of SLC16A1-AS1, miR-194 and SOCS2. Luciferase reporter assay was performed to detect the interaction between SLC16A1-AS1 and miR-194. Colony formation assay was used to detect cell proliferation. Results: SLC16A1-AS1 was down-regulated in CSCC and correlated with poor survival. Overexpression of SLC16A1-AS1 could inhibit the proliferation of cervical cancer cells. In addition, SLC16A1-AS1 could sponge miR-194 and increase the expression levels of SOCS2, ultimately inhibiting the proliferation of cervical cancer cells. Conclusion: SLC16A1-AS1 was downregulated in CSCC and suppressed cell proliferation in cervical squamous cell carcinoma (CSCC) through the miR-194/SOCS2 axis. Keywords: cervical squamous cell carcinoma, SLC16A1-AS1, miR-194, SOCS2
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S276629