Are Chinese Patients with Type 2 Diabetes and a Body Mass Index of 27.5-32.5 kg/m.sup.2 Suitable for Metabolic Surgery? A One-Year Post-Surgery Study

• Published in: Diabetes therapy 2021-05, Vol.12 (5), p.1429
• Main Authors: Zhang, Ning-Jing, Fu, Yu-Zhe, Shan, Xiao-Dong, Zhang, Ning, Sun, Xi-Tai, Chu, Xue-Hui, Bi, Yan
• Format: Article
• Language: English
• Subjects: Body mass index; Care and treatment; Health aspects; Obesity; Surgery; Type 2 diabetes
• ISSN: 1869-6953
• DOI: 10.1007/s13300-021-01027-9

Introduction The aim of this study was to clarify the efficacy and safety of metabolic surgery in Chinese patients with type 2 diabetes mellitus (T2DM) and a body mass index (BMI) of 27.5-32.5 kg/m.sup.2. Methods A total of 99 patients with T2DM were enrolled in this retrospective cohort study. Of these patients, 53 had a BMI of 27.5-32.5 kg/m.sup.2 and had undergone metabolic surgery (n = 21) or were on conventional antidiabetic therapy (n = 32)]; 46 had a BMI [greater than or equal to] 32.5 kg/m.sup.2 and all had undergone metabolic surgery. Primary endpoints included the triple endpoint [hemoglobin A1c < 6.5%, low-density lipoprotein cholesterol (LDL-C) < 2.6 mmol/L, and systolic blood pressure (SBP) < 130 mmHg] and successful weight loss 1 year later. Remission of diabetes, glucose and lipid metabolism, medication usage, and adverse events were evaluated. Results Of patients with BMI 27.5-32.5 kg/m.sup.2 undergoing metabolic surgery, 33.33% achieved the composite endpoints, and 100% achieved successful weight loss. This result was similar to that in patients with BMI [greater than or equal to] 32.5 and better than those with BMI 27.5-32.5 kg/m.sup.2 receiving conventional antidiabetic therapy. A significant and similar reduction in BMI, waist circumference, SBP, serum LDL-C, hemoglobin A1c, and uric acid, as well as similar frequency postoperative adverse events, were confirmed in both metabolic surgery groups. Patients with BMI 27.5-32.5 kg/m.sup.2 who had undergonemetabolic surgery showed more metabolic improvement than those only receiving medications but they experienced more adverse events. Conclusion A BMI cutoff of 27.5 kg/m.sup.2 for metabolic surgery may be suitable for Chinese patients with T2DM.