Orally administered [beta]-glucan improves the hemolytic activity of the complement system in horses

Background and Aim: Immune-modulating molecules mainly act on innate immune cells, which are central to early defense against invading pathogens and contribute to developing adaptive immunity. Yeast-extracted [beta]-glucan, a model immune-modulating molecule, is widely used in several animal species...

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Published in:Veterinary World 2021-04, Vol.14 (4), p.835
Main Authors: Picetti, Taline Scalco, de Figueiredo Soveral, Lucas, Miotto, Rovian, Erpen, Luana Marina Scheer, Kreutz, Yasmin, Guizzo, Joao Antonio, Frandoloso, Rafael, Kreutz, Luiz Carlos
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Language:English
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Ethylenediaminetetraacetic acid
Lysozyme
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container_title Veterinary World
container_volume 14
creator Picetti, Taline Scalco
de Figueiredo Soveral, Lucas
Miotto, Rovian
Erpen, Luana Marina Scheer
Kreutz, Yasmin
Guizzo, Joao Antonio
Frandoloso, Rafael
Kreutz, Luiz Carlos
description Background and Aim: Immune-modulating molecules mainly act on innate immune cells, which are central to early defense against invading pathogens and contribute to developing adaptive immunity. Yeast-extracted [beta]-glucan, a model immune-modulating molecule, is widely used in several animal species; however, its effect on horse immune parameters has not been thoroughly investigated yet. This study aimed to evaluate the effects of orally administered [beta]-glucan on selected innate immune parameters in horses. Materials and Methods: Eighteen thoroughbred horses were assigned equally into three groups as follows: One control group (no [beta]-glucan) and two [beta]-glucan experimental groups (one received 125 mg and the other 2 g of [beta]-glucan per day for 28 days). Blood samples were collected before and at the end of the experiment for hematological analysis, whole blood phagocytosis, respiratory burst assays, and to assess the serum lysozyme and complement hemolytic activities. Results: At the end of the experiment, significant decreases (p
doi_str_mv 10.14202/vetworld.2021.835-840
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Yeast-extracted [beta]-glucan, a model immune-modulating molecule, is widely used in several animal species; however, its effect on horse immune parameters has not been thoroughly investigated yet. This study aimed to evaluate the effects of orally administered [beta]-glucan on selected innate immune parameters in horses. Materials and Methods: Eighteen thoroughbred horses were assigned equally into three groups as follows: One control group (no [beta]-glucan) and two [beta]-glucan experimental groups (one received 125 mg and the other 2 g of [beta]-glucan per day for 28 days). Blood samples were collected before and at the end of the experiment for hematological analysis, whole blood phagocytosis, respiratory burst assays, and to assess the serum lysozyme and complement hemolytic activities. Results: At the end of the experiment, significant decreases (p&lt;0.05) in monocyte numbers were observed in the control horses (258.8[+ or -]45.9 vs. 115.3[+ or -]41.5) and in those fed 125 mg/day of [beta]-glucan (208.8[+ or -]72.3 vs. 99.2[+ or -]60.7), whereas a significant increase in numbers was noted in the horses that were fed 2 g/day of [beta]-glucan (303.5[+ or -]45.8 vs. 429.8[+ or -]86.0; p&lt;0.05). The natural hemolytic activity of the complement was higher only in horses fed 2 g/day of [beta]-glucan (p=0.018) compared to the other groups. The hemolytic activity in the classical pathway was higher in those fed 125 mg/day (p=0.0035) and 2 g/day of [beta]-glucan (p=0.0001). Conclusion: [beta]-glucan improves important innate immune parameters and might be fed to horses before stressful events. Keywords: animals, glucans, monocytes, muramidase.</description><identifier>ISSN: 0972-8988</identifier><identifier>DOI: 10.14202/vetworld.2021.835-840</identifier><language>eng</language><publisher>Veterinary World</publisher><subject>Ethylenediaminetetraacetic acid ; Lysozyme</subject><ispartof>Veterinary World, 2021-04, Vol.14 (4), p.835</ispartof><rights>COPYRIGHT 2021 Veterinary World</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Picetti, Taline Scalco</creatorcontrib><creatorcontrib>de Figueiredo Soveral, Lucas</creatorcontrib><creatorcontrib>Miotto, Rovian</creatorcontrib><creatorcontrib>Erpen, Luana Marina Scheer</creatorcontrib><creatorcontrib>Kreutz, Yasmin</creatorcontrib><creatorcontrib>Guizzo, Joao Antonio</creatorcontrib><creatorcontrib>Frandoloso, Rafael</creatorcontrib><creatorcontrib>Kreutz, Luiz Carlos</creatorcontrib><title>Orally administered [beta]-glucan improves the hemolytic activity of the complement system in horses</title><title>Veterinary World</title><description>Background and Aim: Immune-modulating molecules mainly act on innate immune cells, which are central to early defense against invading pathogens and contribute to developing adaptive immunity. Yeast-extracted [beta]-glucan, a model immune-modulating molecule, is widely used in several animal species; however, its effect on horse immune parameters has not been thoroughly investigated yet. This study aimed to evaluate the effects of orally administered [beta]-glucan on selected innate immune parameters in horses. Materials and Methods: Eighteen thoroughbred horses were assigned equally into three groups as follows: One control group (no [beta]-glucan) and two [beta]-glucan experimental groups (one received 125 mg and the other 2 g of [beta]-glucan per day for 28 days). Blood samples were collected before and at the end of the experiment for hematological analysis, whole blood phagocytosis, respiratory burst assays, and to assess the serum lysozyme and complement hemolytic activities. Results: At the end of the experiment, significant decreases (p&lt;0.05) in monocyte numbers were observed in the control horses (258.8[+ or -]45.9 vs. 115.3[+ or -]41.5) and in those fed 125 mg/day of [beta]-glucan (208.8[+ or -]72.3 vs. 99.2[+ or -]60.7), whereas a significant increase in numbers was noted in the horses that were fed 2 g/day of [beta]-glucan (303.5[+ or -]45.8 vs. 429.8[+ or -]86.0; p&lt;0.05). The natural hemolytic activity of the complement was higher only in horses fed 2 g/day of [beta]-glucan (p=0.018) compared to the other groups. The hemolytic activity in the classical pathway was higher in those fed 125 mg/day (p=0.0035) and 2 g/day of [beta]-glucan (p=0.0001). Conclusion: [beta]-glucan improves important innate immune parameters and might be fed to horses before stressful events. 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Yeast-extracted [beta]-glucan, a model immune-modulating molecule, is widely used in several animal species; however, its effect on horse immune parameters has not been thoroughly investigated yet. This study aimed to evaluate the effects of orally administered [beta]-glucan on selected innate immune parameters in horses. Materials and Methods: Eighteen thoroughbred horses were assigned equally into three groups as follows: One control group (no [beta]-glucan) and two [beta]-glucan experimental groups (one received 125 mg and the other 2 g of [beta]-glucan per day for 28 days). Blood samples were collected before and at the end of the experiment for hematological analysis, whole blood phagocytosis, respiratory burst assays, and to assess the serum lysozyme and complement hemolytic activities. Results: At the end of the experiment, significant decreases (p&lt;0.05) in monocyte numbers were observed in the control horses (258.8[+ or -]45.9 vs. 115.3[+ or -]41.5) and in those fed 125 mg/day of [beta]-glucan (208.8[+ or -]72.3 vs. 99.2[+ or -]60.7), whereas a significant increase in numbers was noted in the horses that were fed 2 g/day of [beta]-glucan (303.5[+ or -]45.8 vs. 429.8[+ or -]86.0; p&lt;0.05). The natural hemolytic activity of the complement was higher only in horses fed 2 g/day of [beta]-glucan (p=0.018) compared to the other groups. The hemolytic activity in the classical pathway was higher in those fed 125 mg/day (p=0.0035) and 2 g/day of [beta]-glucan (p=0.0001). Conclusion: [beta]-glucan improves important innate immune parameters and might be fed to horses before stressful events. Keywords: animals, glucans, monocytes, muramidase.</abstract><pub>Veterinary World</pub><doi>10.14202/vetworld.2021.835-840</doi></addata></record>
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subjects Ethylenediaminetetraacetic acid
Lysozyme
title Orally administered [beta]-glucan improves the hemolytic activity of the complement system in horses
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