The Clinicopathological Findings of 121 Patients Presenting with Spontaneous Nipple Discharge/Meme Basindan Spontan Akinti Sikayeti ile Basvuran 121 Olguya Ait Klinikopatolojik Bulgular

• Published in: Istanbul medical journal 2021-05, Vol.22 (2), p.109
• Main Authors: Sigirci, Buket Bambul, Talu, Canan Kelten, Cakir, Yasemin, Leblebici, Cem, Trabulus, Didem Can
• Format: Article
• Language: eng ; tur
• Subjects: Cancer; Oncology, Experimental
• ISSN: 2619-9793; 1304-8503
• DOI: 10.4274/imj.galenos.2021.67434

Introduction: This study aimed to investigate the cytopathological findings of patients who presented to our hospital with spontaneous nipple discharge. A cytological smear examination was performed to evaluate the correlation between cytology and biopsy in patients whose complementary biopsy or excision sampling was performed. Methods: The nipple discharge smears of 121 patients sent to us over six years were retrospectively reviewed. Acellular smears without any cells were considered "insufficient", and smears that contained ductal cells, inflammatory cells, and foamy histiocytes were considered "sufficient". Smears considered sufficient for microscopic evaluation were classified and reported as "benign cytology", "compatible with papillary lesion", "suspicious for malignancy", and "malignant cytology". Results: When the first smear samples of 121 patients were examined, "malignant cytology" was observed in one patient, "suspicious for malignancy" in two patients, "ductal ectasia" in one hundred and two patients, and "papillary lesion" in fourteen patients. The material was "acellular" in two patients. Nineteen patients were histopathologically diagnosed with malignancy (n=7), ductal ectasia (n=6), intraductal papilloma accompanied by florid-type intraductal hyperplasia without atypia (n=2), intraductal papilloma (n=2), complex sclerosing lesion (n=1), and sclerosing papilloma (n=1). Conclusion: In cases where nipple discharge is persistent, repeated smear samples may contribute to the diagnosis if they contain epithelial components. In cases with histopathologically confirmed breast carcinoma, it should be kept in mind that the tumor may often show neuroendocrine features. Keywords: Breast cancer, neuroendocrine features, ductal ectasia Amac: Bu calismada, hastanemize spontan meme basi akintisi sikayeti ile basvuran ve akintidan yayma yapilan hastalarin sitopatolojik bulgularini arastirmak ve tamamlayici biyopsi ve eksizyon spesmeni olan hastalarda sitoloji ve biyopsi korelasyonunun degerlendirilmesi amaclanmistir. Yontemler: Alti yil suresince tarafimiza gonderilen, 121 hastaya ait meme basi akintisi yaymalari retrospektif olarak incelendi. Hic hucre icermeyen aseluler yaymalar "yetersiz", kopuksu histiosit, enflamatuvar hucre ve duktal hucrelerin izlendigi yaymalar "yeterli" olarak kabul edildi. Mikroskopik inceleme icin yeterli kabul edilen yaymalar, "benign sitoloji", "papiller lezyon ile uyumlu", "malignite suphesi" ve "malign sitoloji" olarak sini