Expression of Genes Encoding Nuclear Factors PPAR[gamma], LXR[beta], and ROR[alpha] in Epicardial and Subcutaneous Adipose Tissues in Patients with Coronary Heart Disease

• Published in: Bulletin of experimental biology and medicine 2021-03, Vol.170 (5), p.654
• Main Authors: Panteleeva, A.A, Razgildina, N.D, Pobozheva, I.A, Polyakova, E.A, Dracheva, K.V, Belyaeva, O.D, Berkovich, O.A, Baranova, E.I, Pchelina, S.N, Miroshnikova, V.V
• Format: Article
• Language: English
• Subjects: Adipose tissues; Blood cholesterol; Care and treatment; Coronary heart disease; Genes; Genetic transcription; Inflammation; Physiological aspects; RNA
• ISSN: 0007-4888
• DOI: 10.1007/s10517-021-05126-2

The nuclear factors PPAR[gamma], ROR[alpha], and LXR[beta] are involved in transcriptional control of adipogenesis and implicated in glucose and lipid metabolism. In adipose tissues, they regulate inflammation. This study focuses on expression of the PPARG, RORA, and LXR[beta] (NR1H2) genes in epicardial and subcutaneous adipose tissues in patients with coronary heart disease as well as with concomitant abdominal obesity. In patients with coronary heart disease and abdominal obesity, PPARG mRNA level in subcutaneous adipose tissue was reduced in comparison with control group. In patients with total coronary occlusions, LXR[beta] mRNA level in epicardial adipose tissue was reduced, and it positively correlated with plasma HDL cholesterol. Thus, in cases of concomitant abdominal obesity and chronic total coronary occlusions, coronary heart disease is characterized by down-regulated expression of the genes of various transcriptional adipogenesis-regulating factors in adipose tissue. Key Words: coronary heart disease; adipose tissue; nuclear factors