The Effects of 6-Week Supplementation with Multicomponent Herbal Extract on Exercise Performance, Antioxidant Status and Telomere Length, and Self-Reported Side Effects in Healthy Men: A Randomized Controlled Pilot Trial

The main aim of this study was to examine the effects of medium-term supplementation with an eight-herPs extract on running performance, biomarkers of antioxidant status and telomere length, and self-reported outcome measures of safety events in healthy men. Ten healthy young men (age 23.1 [+ or -]3...

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Bibliographic Details
Published in:Current Topics in Nutraceutical Research 2021, Vol.19 (4), p.520
Main Authors: Stajer, Valdemar, Todorovic, Nikola, Korovljev, Darinka, Maksimovic, Nebojsa, Miljkovic, Suzana, Ratgeber, Laszlo, Betlehem, Jozsef, Acs, Pongras, Ostojic, Sergej M
Format: Report
Language:English
Subjects:
Analysis
Antioxidants
Clinical trials
Complications and side effects
Dietary supplements
Exercise
Medicine, Botanic
Medicine, Herbal
Superoxide
Telomeres
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Summary:The main aim of this study was to examine the effects of medium-term supplementation with an eight-herPs extract on running performance, biomarkers of antioxidant status and telomere length, and self-reported outcome measures of safety events in healthy men. Ten healthy young men (age 23.1 [+ or -]3.2 years, weight 73.7[+ or -]9.9kg, and height 179.4[+ or -]8.0cm) volunteered to participate in this randomized controlled trial. The participants were allocated in a double-blind cross-over design to receive either an eight-herbs extract or placebo during a 6-week intervention period. Two-way mixed analysis of variance (treatment vs. time interaction) revealed no significant differences for exercise performance outcomes and telomere length between groups (P>0.05). Compared with placebo, P-DNA provoked a significant rise in serum total antioxidant capacity (316.0 [+ or -] 183.4 [micro]mol/mL at baseline; 792.7 [+ or -]68.1 [micro]mol/mL at follow-up in the eight-herbs extract group vs. 298.1 [+ or -]90.7 [micro]mol/ml_ at follow-up in the placebo group; P
ISSN:1540-7535
DOI:10.37290/ctnr2641-452X.19:520-524