Can remote ischemic preconditioning counteract the renal functional deterioration attributable to partial nephrectomy under warm ischemia? Results of an animal study

• Published in: BMC Nephrology 2021, Vol.22 (1)
• Main Authors: Mut, Tuna Till, Acar, ümer, Armutlu, Ayse, Incir, Said, Uhlig, Annemarie, Ertuglu, Lale A, üzel, Melis, Taskin, Ali Cihan, Baydar, Dilek Ertoy, Kanbay, Mehmet, Esen, Tarik
• Format: Report
• Language: English
• Subjects: Care and treatment; Complications and side effects; Ischemia; Kidney failure; Nephrectomy; Prevention; Therapeutics, Physiological; Vasomotor conditioning
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-021-02359-1

To investigate if remote ischemic preconditioning (RIPC) can offer any renoprotective value by counteracting the deleterious effect of partial nephrectomy (PN) under warm ischemia on renal function. Four groups, each with 5 Wistar albino rats, were constructed; RIPC + PN, PN, RIPC and sham. Right nephrectomy was performed to constitute a solitary kidney model. RIPC denoted sequential clamping/declamping of the femoral artery/vein complex. PN was performed under warm-ischemia following RIPC. Blood samples were collected on multiple occasions until euthanasia on day 7. IL-33 levels did not differ significantly between the groups. Serum levels of KIM-1, NGAL, and aldose reductase in RIPC + PN, PN and RIPC groups were significantly lower than that of sham group. Tissue biomarker levels were similar across groups. RIPC failed to counteract the renal functional consequences of PN under warm ischemia in a solitary kidney animal model. The supportive but marginal histological findings in favor of RIPC's renoprotective potential were not supplemented with the changes in serum and tissue biomarker levels.