Talaromyces marneffei and Burkholderia cepacia Co-Infection in a HIV-Uninfected Patient with Anti-Interferon-[gamma] Autoantibodies

A high titer of neutralizing anti-interferon-[gamma] autoantibodies can cause immunodeficiency associated with severe or disseminated infections caused by Talaromyces marneffei in human immunodeficiency virus-negative patients. Herein, we reported a rare case of disseminated Talaromyces marneffei an...

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Bibliographic Details
Published in:Infection and drug resistance 2021-07, Vol.14, p.2173
Main Authors: Zeng, Wen, Qiu, Ye, Tang, Mengxin, Zhang, Hui, Pan, Mianluan, Tang, Shudan, Zhang, Jianquan
Format: Article
Language:English
Subjects:
Autoantibodies
Autoimmunity
Biological response modifiers
Care and treatment
Health aspects
HIV (Viruses)
HIV patients
Interferon
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Summary:A high titer of neutralizing anti-interferon-[gamma] autoantibodies can cause immunodeficiency associated with severe or disseminated infections caused by Talaromyces marneffei in human immunodeficiency virus-negative patients. Herein, we reported a rare case of disseminated Talaromyces marneffei and Burkholderia cepacia infection. The patient's lungs, lymph nodes, and bronchi were involved, and he had neck abscesses and osteomyelitis. We measured the neutralizing anti-interferon-[gamma] autoantibodies in the peripheral blood and found that the patient had a persistently high positive titer. Despite aggressive treatment, the patient developed disseminated intravascular coagulation and died. Thus, high-titer nAIGAs may be associated with multiple opportunistic, persistent and disseminated infections. Keywords: Burkholderia cepacia, Talaromyces marneffei, adult immunodeficiency, neutralizing anti-interferon-Y autoantibodies
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S312042