Analysis of Increased EGFR and IGF-IR Signaling and Its Correlation with Socio-Epidemiological Features and Biological Profile in Breast Cancer Patients: A Study in Northern Brazil

Introduction: Breast cancer (BC) is the second most frequent cancer worldwide. It is known that a subset of BC has amplification, and overexpression of the epidermal growth factor receptor (EGFR) and high expression of the insulin-like growth factor receptor-1 (IGF-1R) are correlated with a favorabl...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2021-05, Vol.13, p.325
Main Authors: Rocha, Francianne Silva, Maues, Jersey Heitor da Silva, Pereira, Cynthia Mara Brito Lins, Aquino, Caroline, Mario, Moreira-Nunes Rommel, Burbano, Rodriguez
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Cancer
Cancer patients
Epidemiology
Epidermal growth factor
Oncology, Experimental
Prognosis
RNA
Scientific equipment and supplies industry
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Summary:Introduction: Breast cancer (BC) is the second most frequent cancer worldwide. It is known that a subset of BC has amplification, and overexpression of the epidermal growth factor receptor (EGFR) and high expression of the insulin-like growth factor receptor-1 (IGF-1R) are correlated with a favorable prognosis. This study aimed to evaluate the prognostic and predictive values of the EGFR and IGF-1R in tumor samples from patients with BC and their correlation with socio-epidemiological features. Patients and Methods: We analyzed socio-epidemiological, clinical-pathological data and tumor tissues from 124 patients with BC undergoing treatment, to assess levels of EGFR and IGF-1R mRNA and protein. The predictive performance included the calculation of area-under-the-curve (AUC) to discriminate groups of patients with high and low mRNA expression associated with survival analysis within each molecular group of BC. Results: We found a significant expression increase (p
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S308554