Comparison of Serum VEGF, IGF-1, and HIF-1[alpha] Levels in Children with Autism Spectrum Disorder and Healthy Controls

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1[alpha] levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1[alpha...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2021-10, Vol.51 (10), p.3564
Main Authors: Simsek, Fulya, Isik, Ümit, Aktepe, Evrim, Kiliç, Faruk, Sirin, Fevziye Burcu, Bozkurt, Mustafa
Format: Article
Language:English
Subjects:
Autism
Children
Comparative analysis
Demographic aspects
Diagnosis
Insulin-like growth factor 1
Metabolism
Pathology
Pervasive Developmental Disorders
Physiology
Preadolescents
Risk factors
Transcription factors
Vascular endothelial growth factor
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Summary:The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1[alpha] levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1[alpha] were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1-[alpha] levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1[alpha] may play a potential role in the etiopathogenesis of ASD.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-020-04820-w