Platelet mitochondrial respiration and coenzyme Q.sub.10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases

Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyper...

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Bibliographic Details
Published in:PloS one 2021-09, Vol.16 (9), p.e0256135
Main Authors: Gvozdjáková, Anna, Sumbalová, Zuzana, Kucharská, Jarmila, Szamosová, Monika, Cápová, Lubica, Rausová, Zuzana, Vancová, Oľga, Mojto, Viliam, Langsjoen, Peter, Palacka, Patrik
Format: Article
Language:English
Subjects:
Blood platelets
Development and progression
Diagnosis
Health aspects
Mitochondria
Physiological aspects
Rheumatoid arthritis
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Summary:Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ.sub.10 levels and oxidative stress in RA patients. Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ.sub.10 was determined by HPLC method; TBARS were detected spectrophotometrically. Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ.sub.10 levels were observed in RA patients compared with normal controls. The observed decrease in platelet CoQ.sub.10 levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ.sub.10 levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0256135