Association Between I nsomnia and Migraine Risk: A Case-Control and Bidirectional Mendelian Randomization Study

Background: The causal relationship between insomnia and migraine is contradictory and no study has been carried out among the Chinese population to date. Methods: In this case, we conducted a case-control study and a bidirectional mendelian randomization (MR) analysis to determine whether insomnia...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2021-09, Vol.14, p.971
Main Authors: Chu, Shujuan, Wu, Zhilin, Wu, Zhouyang, Wu, Jing, Qian, Yue
Format: Article
Language:English
Subjects:
Genomics
Insomnia
Migraine
Type 2 diabetes
Online Access:Get full text
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Summary:Background: The causal relationship between insomnia and migraine is contradictory and no study has been carried out among the Chinese population to date. Methods: In this case, we conducted a case-control study and a bidirectional mendelian randomization (MR) analysis to determine whether insomnia is causally related to the development of migraine. The instrumental variables for insomnia were derived from the largest genome-wide association study of 1,331,010 participants, while the genetic instruments for migraine were available from the largest meta-analysis of migraine with 59,674 cases and 316,078 controls. Results: In case-control study, subjects with insomnia have significantly higher risk of migraine (OR=4.29, 95% CI: 3.21-5.74, P0.05). Conclusion: Conclusively, our study highlighted that increased migraine risk was confined to subjects with a genetic pre-disposition to insomnia, and these findings had potential implications for improving the sleep quality to reduce the burden of migraine. Keywords: mendelian randomization, insomnia, migraine, case-control
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S305780