Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort

The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (Marc...

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Bibliographic Details
Published in:PloS one 2021-10, Vol.16 (10), p.e0258918-e0258918
Main Authors: Zuil, María, Benítez, Iván D., Cabo-Gambín, Ramón, Manzano Senra, Carlos, Moncusí-Moix, Anna, Gort-Paniello, Clara, de Gonzalo-Calvo, David, Molinero, Marta, Vengoechea Aragoncillo, Jose Javier, Comella, Thais, de Batlle, Jordi, Torres, Gerard, Torres, Antoni, Barbé, Ferrán, González, Jessica
Format: Article
Language:English
Subjects:
Antiviral drugs
Biology and Life Sciences
Coronaviruses
COVID-19
Creatinine
Dimers
Disease transmission
Epidemics
Epidemiology
Health aspects
Hospital patients
Hospitalization
Hospitals
Mechanical ventilation
Medicine
Medicine and Health Sciences
Mortality
Nosocomial infections
Observational studies
Patient admissions
Patients
People and places
Physical Sciences
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Supervision
Ventilation
Viral diseases
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Summary:The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0258918